TY - JOUR
T1 - Redefining the roles of the FtsZ-ring in bacterial cytokinesis
AU - Xiao, Jie
AU - Goley, Erin D.
N1 - Funding Information:
We thank members of the Xiao and Goley laboratories, especially Dr. Xinxing Yang, Dr. Carla Coltharp, Elizabeth Meier, and Kousik Sundararajan, as well as Prof. Waldemar Vollmer, Dr. Sean Sun, and Dr. Ganhui Lan for thoughtful discussions during the writing of this manuscript. Work in the Goley and Xiao Laboratories on to the topic of bacterial cytokinesis is supported by the National Institutes of Health [grant numbers R01GM108640 (EDG) and 1R01GM086447 (JX)].
Publisher Copyright:
© 2016
PY - 2016/12/1
Y1 - 2016/12/1
N2 - In most bacteria, cell division relies on the functions of an essential protein, FtsZ. FtsZ polymerizes at the future division site to form a ring-like structure, termed the Z-ring, that serves as a scaffold to recruit all other division proteins, and possibly generates force to constrict the cell. The scaffolding function of the Z-ring is well established, but the force generating function has recently been called into question. Additionally, new findings have demonstrated that the Z-ring is more directly linked to cell wall metabolism than simply recruiting enzymes to the division site. Here we review these advances and suggest that rather than generating a rate-limiting constrictive force, the Z-ring's function may be redefined as an orchestrator of septum synthesis.
AB - In most bacteria, cell division relies on the functions of an essential protein, FtsZ. FtsZ polymerizes at the future division site to form a ring-like structure, termed the Z-ring, that serves as a scaffold to recruit all other division proteins, and possibly generates force to constrict the cell. The scaffolding function of the Z-ring is well established, but the force generating function has recently been called into question. Additionally, new findings have demonstrated that the Z-ring is more directly linked to cell wall metabolism than simply recruiting enzymes to the division site. Here we review these advances and suggest that rather than generating a rate-limiting constrictive force, the Z-ring's function may be redefined as an orchestrator of septum synthesis.
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U2 - 10.1016/j.mib.2016.08.008
DO - 10.1016/j.mib.2016.08.008
M3 - Review article
C2 - 27620716
AN - SCOPUS:84986592707
SN - 1369-5274
VL - 34
SP - 90
EP - 96
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
ER -