Red grape seed extract improves lipid profiles and decreases oxidized low-density lipoprotein in patients with mild hyperlipidemia

Seyed Mostafa Razavi, Sharareh Gholamin, Ali Eskandari, Nakta Mohsenian, Amir Ghorbanihaghjo, Abbas Delazar, Nadereh Rashtchizadeh, Maryam Keshtkar-Jahromi, Hassan Argani

Research output: Contribution to journalArticle

Abstract

Hyperlipidemia can lead to atherosclerosis by lipoprotein deposition inside the vessel wall and oxidative stress induction that leads to the formation of atherosclerotic plaque. Oxidized low-density lipoprotein particles (Ox-LDL) have a key role in the pathogenesis of atherosclerosis. The lipid-lowering properties and antioxidants of the grape seed can be beneficial in atherosclerosis prevention. We conducted a randomized double-blind placebo-controlled crossover clinical trial. Fifty-two mildly hyperlipidemic individuals were divided into two groups that received either 200 mg/day of the red grape seed extract (RGSE) or placebo for 8 weeks. After an 8-week washout period, the groups were crossed over for another 8 weeks. Lipid profiles and Ox-LDL were measured at the beginning and the end of each phase. RGSE consumption reduced total cholesterol (-10.68±26.76 mg/dL, P=.015), LDL cholesterol (-9.66±23.92 mg/dL, P=.014), and Ox-LDL (-5.47±12.12 mg/dL, P=.008). While triglyceride and very low-density lipoprotein cholesterol were decreased and high-density lipoprotein cholesterol was increased by RGSE, the changes were not statistically significant. RGSE consumption decreases Ox-LDL and has beneficial effects on lipid profile - consequently decreasing the risk of atherosclerosis and cardiovascular disorders - in mild hyperlipidemic individuals.

Original languageEnglish (US)
Pages (from-to)255-258
Number of pages4
JournalJournal of Medicinal Food
Volume16
Issue number3
DOIs
StatePublished - Mar 1 2013
Externally publishedYes

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Keywords

  • Atherosclerosis
  • Grape seed extract
  • Lipid profile
  • Oxidative stress

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Razavi, S. M., Gholamin, S., Eskandari, A., Mohsenian, N., Ghorbanihaghjo, A., Delazar, A., Rashtchizadeh, N., Keshtkar-Jahromi, M., & Argani, H. (2013). Red grape seed extract improves lipid profiles and decreases oxidized low-density lipoprotein in patients with mild hyperlipidemia. Journal of Medicinal Food, 16(3), 255-258. https://doi.org/10.1089/jmf.2012.2408