Red Cell distribution width and mortality in older adults

A meta-analysis

Kushang V. Patel, Richard David Semba, Luigi Ferrucci, Anne B. Newman, Linda P Fried, Robert B. Wallace, Stefania Bandinelli, Caroline S. Phillips, Binbing Yu, Stephanie Connelly, Michael G. Shlipak, Paulo H M Chaves, Lenore J. Launer, William B. Ershler, Tamara B. Harris, Dan L. Longo, Jack M. Guralnik

Research output: Contribution to journalArticle

Abstract

BackgroundRed cell distribution width (RDW) is a quantitative measure of variability in the size of circulating erythrocytes with higher values reflecting greater heterogeneity in cell sizes. Recent studies have shown that higher RDW is associated with increased mortality risk in patients with clinically significant cardiovascular disease (CVD). Whether RDW is prognostic in more representative community-based populations is unclear.MethodsSeven relevant community-based studies of older adults with RDW measurement and mortality ascertainment were identified. Cox proportional hazards regression and meta-analysis on individual participant data were performed.ResultsMedian RDW values varied across studies from 13.2% to 14.6%. During 68,822 person-years of follow-up of 11,827 older adults with RDW measured, there was a graded increased risk of death associated with higher RDW values (p

Original languageEnglish (US)
Pages (from-to)258-265
Number of pages8
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume65 A
Issue number3
DOIs
StatePublished - Mar 2010

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Erythrocyte Indices
Meta-Analysis
Mortality
Cell Size
Cardiovascular Diseases
Erythrocytes
Regression Analysis
Population

Keywords

  • Aging
  • Erythrocyte Indices
  • Mortality
  • Risk Factors

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology
  • Medicine(all)

Cite this

Red Cell distribution width and mortality in older adults : A meta-analysis. / Patel, Kushang V.; Semba, Richard David; Ferrucci, Luigi; Newman, Anne B.; Fried, Linda P; Wallace, Robert B.; Bandinelli, Stefania; Phillips, Caroline S.; Yu, Binbing; Connelly, Stephanie; Shlipak, Michael G.; Chaves, Paulo H M; Launer, Lenore J.; Ershler, William B.; Harris, Tamara B.; Longo, Dan L.; Guralnik, Jack M.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 65 A, No. 3, 03.2010, p. 258-265.

Research output: Contribution to journalArticle

Patel, KV, Semba, RD, Ferrucci, L, Newman, AB, Fried, LP, Wallace, RB, Bandinelli, S, Phillips, CS, Yu, B, Connelly, S, Shlipak, MG, Chaves, PHM, Launer, LJ, Ershler, WB, Harris, TB, Longo, DL & Guralnik, JM 2010, 'Red Cell distribution width and mortality in older adults: A meta-analysis', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 65 A, no. 3, pp. 258-265. https://doi.org/10.1093/gerona/glp163
Patel, Kushang V. ; Semba, Richard David ; Ferrucci, Luigi ; Newman, Anne B. ; Fried, Linda P ; Wallace, Robert B. ; Bandinelli, Stefania ; Phillips, Caroline S. ; Yu, Binbing ; Connelly, Stephanie ; Shlipak, Michael G. ; Chaves, Paulo H M ; Launer, Lenore J. ; Ershler, William B. ; Harris, Tamara B. ; Longo, Dan L. ; Guralnik, Jack M. / Red Cell distribution width and mortality in older adults : A meta-analysis. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2010 ; Vol. 65 A, No. 3. pp. 258-265.
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AU - Wallace, Robert B.

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