Red cell cotransport activity and Sodium content in black men: Relationship to Essential hypertension

Richard E. Ringel, John M. Hamlyn, Juergen Schaeffer, Bruce P. Hamilton, Avinoam A. Kowarski, Mordecai P. Blaustein, Mlchael A. Berman

Research output: Contribution to journalArticlepeer-review


Furosemide-sensitive sodium and potassium cotransport and intracellular sodium content ([Na],) were measured in erythrocytes (red blood cells, RBCs) from a population of 90 adult black men with and without essential hypertension (EH). The mean values for sodium cotransport activity, expressed as furosemide-sensitive Na efflux (mmol/liter RBC/hr), were not significantly different among the EH patients and two control groups, normotensive subjects with a positive history (N+) and those with a negative family history (N-) for hypertensive disease (EH: 154 ± 123, n = 53; N+:167 ± 93, n = 12; and N~: 207 ± 142, n = 20; all values are means ± SD). The mean [Na], 9.66 ± 3.02 mmol/liter RBC (n = 56) for the EH group was greater than the mean value for the N~ control group (7.96 ± 1.97, n = 20; p < 0.05). The N+ group also displayed a higher mean [Na], (10.38 ± 3.18, n = 12; N+ vsN~ p < 0.01). Although there was substantial overlapping of [Na], values between the groups and no clear dividing line, the distribution curve of the [Na], values in EH was skewed toward higher concentrations than in N~. Nevertheless, we must conclude that erythrocyte cotransport and [Na], are not clinically useful in the identification of EH in black men.

Original languageEnglish (US)
Pages (from-to)724-730
Number of pages7
Issue number5
StatePublished - 1984


  • Erythrocyte
  • Essential hypertension
  • Sodium

ASJC Scopus subject areas

  • Internal Medicine

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