Red blood cell transfusions increase fecal calprotectin levels in premature infants

T. T.B. Ho; M. W. Groer; A. A. Luciano; A. Schwartz; M. Ji; B. S. Miladinovic; A. Maheshwari; T. L. Ashmeade

doi:10.1038/jp.2015.73

Red blood cell transfusions increase fecal calprotectin levels in premature infants

T. T.B. Ho, M. W. Groer, A. A. Luciano, A. Schwartz, M. Ji, B. S. Miladinovic, A. Maheshwari, T. L. Ashmeade

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Objective: We hypothesized that red blood cell (RBC) transfusions influence intestinal inflammation in very low birth weight (VLBW) infants. We also suspected that hematocrit (Hct) at transfusions and RBC storage time correlate with intestinal inflammation. Study Design: VLBW infants, without major congenital defects, intestinal perforation or necrotizing enterocolitis, were enrolled prospectively. Fecal calprotectin (FC) levels were measured from stool samples collected before and after RBC transfusions. Data on Hct and RBC storage time were collected. Result: Data from 42 RBC transfusions given to 26 infants revealed that FC levels increased faster than baseline after RBC transfusions (P=0.018) and were higher in multiple-transfused infants (0 to 48 and >48 h post transfusion, P=0.007 and P=0.005, respectively). Lower Hct and RBC storage >21 days correlated with higher FC levels (P=0.044 and P=0.013, respectively). Conclusion: RBC transfusions, anemia and prolonged RBC storage were associated with an increase in intestinal inflammation.

Original language	English (US)
Pages (from-to)	837-841
Number of pages	5
Journal	Journal of Perinatology
Volume	35
Issue number	10
DOIs	https://doi.org/10.1038/jp.2015.73
State	Published - Oct 1 2015
Externally published	Yes

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynecology

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10.1038/jp.2015.73

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title = "Red blood cell transfusions increase fecal calprotectin levels in premature infants",

abstract = "Objective: We hypothesized that red blood cell (RBC) transfusions influence intestinal inflammation in very low birth weight (VLBW) infants. We also suspected that hematocrit (Hct) at transfusions and RBC storage time correlate with intestinal inflammation. Study Design: VLBW infants, without major congenital defects, intestinal perforation or necrotizing enterocolitis, were enrolled prospectively. Fecal calprotectin (FC) levels were measured from stool samples collected before and after RBC transfusions. Data on Hct and RBC storage time were collected. Result: Data from 42 RBC transfusions given to 26 infants revealed that FC levels increased faster than baseline after RBC transfusions (P=0.018) and were higher in multiple-transfused infants (0 to 48 and >48 h post transfusion, P=0.007 and P=0.005, respectively). Lower Hct and RBC storage >21 days correlated with higher FC levels (P=0.044 and P=0.013, respectively). Conclusion: RBC transfusions, anemia and prolonged RBC storage were associated with an increase in intestinal inflammation.",

author = "Ho, {T. T.B.} and Groer, {M. W.} and Luciano, {A. A.} and A. Schwartz and M. Ji and Miladinovic, {B. S.} and A. Maheshwari and Ashmeade, {T. L.}",

note = "Funding Information: We thank the research nurses, Judy Zaritt and Shari Roberts, for their valuable contribution in the identification of eligible infants, collection of clinical information and collection of stool samples; Tampa General Hospital NICU nurses for saving the stool samples; laboratory technicians, Bradley Kane and Shaunte Williams, for their assistance with processing of samples and with ELISA; Dr Emmanuel for her encouragement and enduring support; and Dr Jane Carver for patiently editing the grant proposal and manuscript. The study was funded by the Gerber Foundation Novice Research Award (to TTBH), Fremont, MI, USA, and by the National Institution of Health (NIH) award R01HD059142 (to AM). Publisher Copyright: {\textcopyright} 2015 Nature America, Inc. All rights reserved.",

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doi = "10.1038/jp.2015.73",

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T1 - Red blood cell transfusions increase fecal calprotectin levels in premature infants

AU - Ho, T. T.B.

AU - Groer, M. W.

AU - Luciano, A. A.

AU - Schwartz, A.

AU - Ji, M.

AU - Miladinovic, B. S.

AU - Maheshwari, A.

AU - Ashmeade, T. L.

N1 - Funding Information: We thank the research nurses, Judy Zaritt and Shari Roberts, for their valuable contribution in the identification of eligible infants, collection of clinical information and collection of stool samples; Tampa General Hospital NICU nurses for saving the stool samples; laboratory technicians, Bradley Kane and Shaunte Williams, for their assistance with processing of samples and with ELISA; Dr Emmanuel for her encouragement and enduring support; and Dr Jane Carver for patiently editing the grant proposal and manuscript. The study was funded by the Gerber Foundation Novice Research Award (to TTBH), Fremont, MI, USA, and by the National Institution of Health (NIH) award R01HD059142 (to AM). Publisher Copyright: © 2015 Nature America, Inc. All rights reserved.

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Objective: We hypothesized that red blood cell (RBC) transfusions influence intestinal inflammation in very low birth weight (VLBW) infants. We also suspected that hematocrit (Hct) at transfusions and RBC storage time correlate with intestinal inflammation. Study Design: VLBW infants, without major congenital defects, intestinal perforation or necrotizing enterocolitis, were enrolled prospectively. Fecal calprotectin (FC) levels were measured from stool samples collected before and after RBC transfusions. Data on Hct and RBC storage time were collected. Result: Data from 42 RBC transfusions given to 26 infants revealed that FC levels increased faster than baseline after RBC transfusions (P=0.018) and were higher in multiple-transfused infants (0 to 48 and >48 h post transfusion, P=0.007 and P=0.005, respectively). Lower Hct and RBC storage >21 days correlated with higher FC levels (P=0.044 and P=0.013, respectively). Conclusion: RBC transfusions, anemia and prolonged RBC storage were associated with an increase in intestinal inflammation.

AB - Objective: We hypothesized that red blood cell (RBC) transfusions influence intestinal inflammation in very low birth weight (VLBW) infants. We also suspected that hematocrit (Hct) at transfusions and RBC storage time correlate with intestinal inflammation. Study Design: VLBW infants, without major congenital defects, intestinal perforation or necrotizing enterocolitis, were enrolled prospectively. Fecal calprotectin (FC) levels were measured from stool samples collected before and after RBC transfusions. Data on Hct and RBC storage time were collected. Result: Data from 42 RBC transfusions given to 26 infants revealed that FC levels increased faster than baseline after RBC transfusions (P=0.018) and were higher in multiple-transfused infants (0 to 48 and >48 h post transfusion, P=0.007 and P=0.005, respectively). Lower Hct and RBC storage >21 days correlated with higher FC levels (P=0.044 and P=0.013, respectively). Conclusion: RBC transfusions, anemia and prolonged RBC storage were associated with an increase in intestinal inflammation.

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Red blood cell transfusions increase fecal calprotectin levels in premature infants

Abstract

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