Red blood cell transfusion in the treatment and management of anaemia: The search for the elusive transfusion trigger

J. K. Wang, H. G. Klein

Research output: Contribution to journalArticle


Therapeutic red blood cell (RBC) transfusion is widely utilized in the management of anaemia. Critically ill intensive care unit (ICU) patients in particular, as well as medical and haematology-oncology patients, are among the largest groups of users of RBC products. While anaemia is common in these patients, its treatment and management, including appropriate thresholds for RBC transfusion, remain controversial. We review here the function of RBCs in oxygen transport and physiology, with a view to their role in supporting and maintaining systemic tissue oxygenation. Adaptive and physiological compensatory mechanisms in the setting of anaemia are discussed, along with the limits of compensation. Finally, data from clinical studies will be examined in search of evidence for, or against, a clinically relevant transfusion trigger.

Original languageEnglish (US)
Pages (from-to)2-11
Number of pages10
JournalVox Sanguinis
Issue number1
StatePublished - Jan 2010
Externally publishedYes


ASJC Scopus subject areas

  • Hematology

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