Red blood cell metallothionein as an indicator of zinc status during pregnancy

Laura Caulfield, Carmen M. Donangelo, Ping Chen, Jorge Junco, Mario Merialdi, Nelly Zavaleta

Research output: Contribution to journalArticle

Abstract

Objective: We describe the levels and patterns of change in red blood cell (RBC) metallothionein (MT) during pregnancy and the neonate and relate RBCMT to other indicators of zinc and iron status. Methods: As part of a double-masked controlled trial of prenatal zinc supplementation among 242 Peruvian pregnant women, we determined RBCMT at enrollment (10-16 wk), at 28 and 36 wk of gestation, and in the cord blood at delivery in 158 women (86 who received daily supplements containing 60 mg of iron and 250 μg of folic acid and 72 whose supplements also contained 25 mg of zinc). In addition, we measured plasma and urinary zinc concentrations, hemoglobin and serum ferritin, and, on a limited sample, RBC zinc and placental MT. Results: RBCMT increased during pregnancy, and levels in the cord blood approximated maternal values at 36 wk. Only RBC zinc at 36 wk differed by supplement type (P <0.05). Increases in RBCMT over pregnancy were, however, related to early pregnancy RBC zinc and inversely with the decline in plasma zinc from baseline to 36 wk of gestation. Conclusion: Changes in RBCMT throughout pregnancy were consistent with the hypothesized role of MT in regulating zinc homeostasis. RBCMT appears to not be responsive during pregnancy to changes in zinc status achieved with supplements.

Original languageEnglish (US)
Pages (from-to)1081-1087
Number of pages7
JournalNutrition (Burbank, Los Angeles County, Calif.)
Volume24
Issue number11-12
DOIs
StatePublished - Nov 2008

Fingerprint

Metallothionein
Zinc
Erythrocytes
Pregnancy
Fetal Blood
Iron
Ferritins
Folic Acid
Pregnant Women
Homeostasis
Mothers
Newborn Infant
Serum

Keywords

  • Erythrocyte
  • Iron
  • Metallothionein
  • Pregnancy
  • Zinc

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Red blood cell metallothionein as an indicator of zinc status during pregnancy. / Caulfield, Laura; Donangelo, Carmen M.; Chen, Ping; Junco, Jorge; Merialdi, Mario; Zavaleta, Nelly.

In: Nutrition (Burbank, Los Angeles County, Calif.), Vol. 24, No. 11-12, 11.2008, p. 1081-1087.

Research output: Contribution to journalArticle

Caulfield, Laura ; Donangelo, Carmen M. ; Chen, Ping ; Junco, Jorge ; Merialdi, Mario ; Zavaleta, Nelly. / Red blood cell metallothionein as an indicator of zinc status during pregnancy. In: Nutrition (Burbank, Los Angeles County, Calif.). 2008 ; Vol. 24, No. 11-12. pp. 1081-1087.
@article{344ef93989ad43d291452f3d1416df3d,
title = "Red blood cell metallothionein as an indicator of zinc status during pregnancy",
abstract = "Objective: We describe the levels and patterns of change in red blood cell (RBC) metallothionein (MT) during pregnancy and the neonate and relate RBCMT to other indicators of zinc and iron status. Methods: As part of a double-masked controlled trial of prenatal zinc supplementation among 242 Peruvian pregnant women, we determined RBCMT at enrollment (10-16 wk), at 28 and 36 wk of gestation, and in the cord blood at delivery in 158 women (86 who received daily supplements containing 60 mg of iron and 250 μg of folic acid and 72 whose supplements also contained 25 mg of zinc). In addition, we measured plasma and urinary zinc concentrations, hemoglobin and serum ferritin, and, on a limited sample, RBC zinc and placental MT. Results: RBCMT increased during pregnancy, and levels in the cord blood approximated maternal values at 36 wk. Only RBC zinc at 36 wk differed by supplement type (P <0.05). Increases in RBCMT over pregnancy were, however, related to early pregnancy RBC zinc and inversely with the decline in plasma zinc from baseline to 36 wk of gestation. Conclusion: Changes in RBCMT throughout pregnancy were consistent with the hypothesized role of MT in regulating zinc homeostasis. RBCMT appears to not be responsive during pregnancy to changes in zinc status achieved with supplements.",
keywords = "Erythrocyte, Iron, Metallothionein, Pregnancy, Zinc",
author = "Laura Caulfield and Donangelo, {Carmen M.} and Ping Chen and Jorge Junco and Mario Merialdi and Nelly Zavaleta",
year = "2008",
month = "11",
doi = "10.1016/j.nut.2008.05.011",
language = "English (US)",
volume = "24",
pages = "1081--1087",
journal = "Nutrition",
issn = "0899-9007",
publisher = "Elsevier Inc.",
number = "11-12",

}

TY - JOUR

T1 - Red blood cell metallothionein as an indicator of zinc status during pregnancy

AU - Caulfield, Laura

AU - Donangelo, Carmen M.

AU - Chen, Ping

AU - Junco, Jorge

AU - Merialdi, Mario

AU - Zavaleta, Nelly

PY - 2008/11

Y1 - 2008/11

N2 - Objective: We describe the levels and patterns of change in red blood cell (RBC) metallothionein (MT) during pregnancy and the neonate and relate RBCMT to other indicators of zinc and iron status. Methods: As part of a double-masked controlled trial of prenatal zinc supplementation among 242 Peruvian pregnant women, we determined RBCMT at enrollment (10-16 wk), at 28 and 36 wk of gestation, and in the cord blood at delivery in 158 women (86 who received daily supplements containing 60 mg of iron and 250 μg of folic acid and 72 whose supplements also contained 25 mg of zinc). In addition, we measured plasma and urinary zinc concentrations, hemoglobin and serum ferritin, and, on a limited sample, RBC zinc and placental MT. Results: RBCMT increased during pregnancy, and levels in the cord blood approximated maternal values at 36 wk. Only RBC zinc at 36 wk differed by supplement type (P <0.05). Increases in RBCMT over pregnancy were, however, related to early pregnancy RBC zinc and inversely with the decline in plasma zinc from baseline to 36 wk of gestation. Conclusion: Changes in RBCMT throughout pregnancy were consistent with the hypothesized role of MT in regulating zinc homeostasis. RBCMT appears to not be responsive during pregnancy to changes in zinc status achieved with supplements.

AB - Objective: We describe the levels and patterns of change in red blood cell (RBC) metallothionein (MT) during pregnancy and the neonate and relate RBCMT to other indicators of zinc and iron status. Methods: As part of a double-masked controlled trial of prenatal zinc supplementation among 242 Peruvian pregnant women, we determined RBCMT at enrollment (10-16 wk), at 28 and 36 wk of gestation, and in the cord blood at delivery in 158 women (86 who received daily supplements containing 60 mg of iron and 250 μg of folic acid and 72 whose supplements also contained 25 mg of zinc). In addition, we measured plasma and urinary zinc concentrations, hemoglobin and serum ferritin, and, on a limited sample, RBC zinc and placental MT. Results: RBCMT increased during pregnancy, and levels in the cord blood approximated maternal values at 36 wk. Only RBC zinc at 36 wk differed by supplement type (P <0.05). Increases in RBCMT over pregnancy were, however, related to early pregnancy RBC zinc and inversely with the decline in plasma zinc from baseline to 36 wk of gestation. Conclusion: Changes in RBCMT throughout pregnancy were consistent with the hypothesized role of MT in regulating zinc homeostasis. RBCMT appears to not be responsive during pregnancy to changes in zinc status achieved with supplements.

KW - Erythrocyte

KW - Iron

KW - Metallothionein

KW - Pregnancy

KW - Zinc

UR - http://www.scopus.com/inward/record.url?scp=53449084213&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=53449084213&partnerID=8YFLogxK

U2 - 10.1016/j.nut.2008.05.011

DO - 10.1016/j.nut.2008.05.011

M3 - Article

C2 - 18602250

AN - SCOPUS:53449084213

VL - 24

SP - 1081

EP - 1087

JO - Nutrition

JF - Nutrition

SN - 0899-9007

IS - 11-12

ER -