Recurrent urinary tract infections in children with bladder and bowel dysfunction

Nader Shaikh, Alejandro Hoberman, Ron Keren, Nathan Gotman, Steven G. Docimo, Ranjiv Mathews, Sonika Bhatnagar, Anastasia Ivanova, Tej K. Mattoo, Marva Moxey-Mims, Myra A. Carpenter, Hans G. Pohl, Saul Greenfield

Research output: Contribution to journalArticle

Abstract

Background: Little generalizable information is available on the outcomes of children diagnosed with bladder and bowel dysfunction (BBD) after a urinary tract infection (UTI). Our objectives were to describe the clinical characteristics of children with BBD and to examine the effects of BBD on patient outcomes in children with and without vesicoureteral reflux (VUR). Methods: We combined data from 2 longitudinal studies (Randomized Intervention for Children With Vesicoureteral Reflux and Careful Urinary Tract Infection Evaluation) in which children <6 years of age with a first or second UTI were followed for 2 years. We compared outcomes for children with and without BBD, children with and without VUR, and children with VUR randomly assigned to prophylaxis or placebo. The outcomes examined were incidence of recurrent UTIs, renal scarring, surgical intervention, resolution of VUR, and treatment failure. Results: BBD was present at baseline in 54% of the 181 toilet-trained children included; 94% of children with BBD reported daytime wetting, withholding maneuvers, or constipation. In children not on antimicrobial prophylaxis, 51% of those with both BBD and VUR experienced recurrent UTIs, compared with 20% of those with VUR alone, 35% with BBD alone, and 32% with neither BBD nor VUR. BBD was not associated with any of the other outcomes investigated. Conclusions: Among toilet-trained children, those with both BBD and VUR are at higher risk of developing recurrent UTIs than children with isolated VUR or children wit.

Original languageEnglish (US)
Article numbere20152982
JournalPediatrics
Volume137
Issue number1
DOIs
StatePublished - Jan 1 2016
Externally publishedYes

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Urinary Tract Infections
Vesico-Ureteral Reflux
Urinary Bladder
Diurnal Enuresis
Wit and Humor
Constipation
Treatment Failure
Cicatrix
Longitudinal Studies
Placebos

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Shaikh, N., Hoberman, A., Keren, R., Gotman, N., Docimo, S. G., Mathews, R., ... Greenfield, S. (2016). Recurrent urinary tract infections in children with bladder and bowel dysfunction. Pediatrics, 137(1), [e20152982]. https://doi.org/10.1542/peds.2015-2982

Recurrent urinary tract infections in children with bladder and bowel dysfunction. / Shaikh, Nader; Hoberman, Alejandro; Keren, Ron; Gotman, Nathan; Docimo, Steven G.; Mathews, Ranjiv; Bhatnagar, Sonika; Ivanova, Anastasia; Mattoo, Tej K.; Moxey-Mims, Marva; Carpenter, Myra A.; Pohl, Hans G.; Greenfield, Saul.

In: Pediatrics, Vol. 137, No. 1, e20152982, 01.01.2016.

Research output: Contribution to journalArticle

Shaikh, N, Hoberman, A, Keren, R, Gotman, N, Docimo, SG, Mathews, R, Bhatnagar, S, Ivanova, A, Mattoo, TK, Moxey-Mims, M, Carpenter, MA, Pohl, HG & Greenfield, S 2016, 'Recurrent urinary tract infections in children with bladder and bowel dysfunction', Pediatrics, vol. 137, no. 1, e20152982. https://doi.org/10.1542/peds.2015-2982
Shaikh N, Hoberman A, Keren R, Gotman N, Docimo SG, Mathews R et al. Recurrent urinary tract infections in children with bladder and bowel dysfunction. Pediatrics. 2016 Jan 1;137(1). e20152982. https://doi.org/10.1542/peds.2015-2982
Shaikh, Nader ; Hoberman, Alejandro ; Keren, Ron ; Gotman, Nathan ; Docimo, Steven G. ; Mathews, Ranjiv ; Bhatnagar, Sonika ; Ivanova, Anastasia ; Mattoo, Tej K. ; Moxey-Mims, Marva ; Carpenter, Myra A. ; Pohl, Hans G. ; Greenfield, Saul. / Recurrent urinary tract infections in children with bladder and bowel dysfunction. In: Pediatrics. 2016 ; Vol. 137, No. 1.
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AU - Mathews, Ranjiv

AU - Bhatnagar, Sonika

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