Recurrent pleomorphic adenoma of the parotid gland: Long-term outcome of patients treated with radiation therapy

Allen M. Chen, Joaquin Garcia, M. Kara Bucci, Jeanne M. Quivey, David W Eisele

Research output: Contribution to journalArticle

Abstract

Purpose: To evaluate the role of radiation therapy in the management of recurrent pleomorphic adenoma of the parotid gland. Methods and Materials: Between 1960 and 2004, 34 patients were treated with postoperative radiation therapy for recurrent pleomorphic adenoma of the parotid gland to a median dose of 5000 cGy (range, 4,500-6,000 cGy). Median age was 48 years (range, 24-72 years). Gross total resection at the time of surgery before radiation was achieved in 30 patients (88%), and histologic analysis demonstrated multifocal disease in 16 patients (47%). Radiation was delivered for a first, second, third, fourth, fifth, and sixth local recurrence in 24%, 21%, 24%, 24%, 6%, and 3% of patients, respectively. Results: With a median follow-up of 17.4 years (range, 2.3-28.9 years), 2 patients had local recurrences at a median of 3.4 years after completion of radiation. The 20-year actuarial local control rate was 94%. One patient developed a second malignancy at approximately 14 years after completion of therapy. Conclusion: The use of postoperative radiation therapy leads to excellent long-term local control for the treatment of recurrent pleomorphic adenoma with acceptable late toxicity. Although the incidence of second malignancy was low in this population, continued follow-up is warranted.

Original languageEnglish (US)
Pages (from-to)1031-1035
Number of pages5
JournalInternational Journal of Radiation Oncology, Biology, Physics
Volume66
Issue number4
DOIs
StatePublished - Nov 15 2006
Externally publishedYes

Fingerprint

salivary glands
Pleomorphic Adenoma
Parotid Gland
radiation therapy
Radiotherapy
Second Primary Neoplasms
Radiation
radiation
Recurrence
surgery
toxicity
therapy
incidence
dosage
Incidence
Therapeutics
Population

Keywords

  • Parotid gland
  • Pleomorphic adenoma
  • Radiation therapy
  • Recurrence

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

Cite this

Recurrent pleomorphic adenoma of the parotid gland : Long-term outcome of patients treated with radiation therapy. / Chen, Allen M.; Garcia, Joaquin; Bucci, M. Kara; Quivey, Jeanne M.; Eisele, David W.

In: International Journal of Radiation Oncology, Biology, Physics, Vol. 66, No. 4, 15.11.2006, p. 1031-1035.

Research output: Contribution to journalArticle

@article{063a43be3165477180b0ed5e4e9f75ab,
title = "Recurrent pleomorphic adenoma of the parotid gland: Long-term outcome of patients treated with radiation therapy",
abstract = "Purpose: To evaluate the role of radiation therapy in the management of recurrent pleomorphic adenoma of the parotid gland. Methods and Materials: Between 1960 and 2004, 34 patients were treated with postoperative radiation therapy for recurrent pleomorphic adenoma of the parotid gland to a median dose of 5000 cGy (range, 4,500-6,000 cGy). Median age was 48 years (range, 24-72 years). Gross total resection at the time of surgery before radiation was achieved in 30 patients (88{\%}), and histologic analysis demonstrated multifocal disease in 16 patients (47{\%}). Radiation was delivered for a first, second, third, fourth, fifth, and sixth local recurrence in 24{\%}, 21{\%}, 24{\%}, 24{\%}, 6{\%}, and 3{\%} of patients, respectively. Results: With a median follow-up of 17.4 years (range, 2.3-28.9 years), 2 patients had local recurrences at a median of 3.4 years after completion of radiation. The 20-year actuarial local control rate was 94{\%}. One patient developed a second malignancy at approximately 14 years after completion of therapy. Conclusion: The use of postoperative radiation therapy leads to excellent long-term local control for the treatment of recurrent pleomorphic adenoma with acceptable late toxicity. Although the incidence of second malignancy was low in this population, continued follow-up is warranted.",
keywords = "Parotid gland, Pleomorphic adenoma, Radiation therapy, Recurrence",
author = "Chen, {Allen M.} and Joaquin Garcia and Bucci, {M. Kara} and Quivey, {Jeanne M.} and Eisele, {David W}",
year = "2006",
month = "11",
day = "15",
doi = "10.1016/j.ijrobp.2006.06.036",
language = "English (US)",
volume = "66",
pages = "1031--1035",
journal = "International Journal of Radiation Oncology Biology Physics",
issn = "0360-3016",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - Recurrent pleomorphic adenoma of the parotid gland

T2 - Long-term outcome of patients treated with radiation therapy

AU - Chen, Allen M.

AU - Garcia, Joaquin

AU - Bucci, M. Kara

AU - Quivey, Jeanne M.

AU - Eisele, David W

PY - 2006/11/15

Y1 - 2006/11/15

N2 - Purpose: To evaluate the role of radiation therapy in the management of recurrent pleomorphic adenoma of the parotid gland. Methods and Materials: Between 1960 and 2004, 34 patients were treated with postoperative radiation therapy for recurrent pleomorphic adenoma of the parotid gland to a median dose of 5000 cGy (range, 4,500-6,000 cGy). Median age was 48 years (range, 24-72 years). Gross total resection at the time of surgery before radiation was achieved in 30 patients (88%), and histologic analysis demonstrated multifocal disease in 16 patients (47%). Radiation was delivered for a first, second, third, fourth, fifth, and sixth local recurrence in 24%, 21%, 24%, 24%, 6%, and 3% of patients, respectively. Results: With a median follow-up of 17.4 years (range, 2.3-28.9 years), 2 patients had local recurrences at a median of 3.4 years after completion of radiation. The 20-year actuarial local control rate was 94%. One patient developed a second malignancy at approximately 14 years after completion of therapy. Conclusion: The use of postoperative radiation therapy leads to excellent long-term local control for the treatment of recurrent pleomorphic adenoma with acceptable late toxicity. Although the incidence of second malignancy was low in this population, continued follow-up is warranted.

AB - Purpose: To evaluate the role of radiation therapy in the management of recurrent pleomorphic adenoma of the parotid gland. Methods and Materials: Between 1960 and 2004, 34 patients were treated with postoperative radiation therapy for recurrent pleomorphic adenoma of the parotid gland to a median dose of 5000 cGy (range, 4,500-6,000 cGy). Median age was 48 years (range, 24-72 years). Gross total resection at the time of surgery before radiation was achieved in 30 patients (88%), and histologic analysis demonstrated multifocal disease in 16 patients (47%). Radiation was delivered for a first, second, third, fourth, fifth, and sixth local recurrence in 24%, 21%, 24%, 24%, 6%, and 3% of patients, respectively. Results: With a median follow-up of 17.4 years (range, 2.3-28.9 years), 2 patients had local recurrences at a median of 3.4 years after completion of radiation. The 20-year actuarial local control rate was 94%. One patient developed a second malignancy at approximately 14 years after completion of therapy. Conclusion: The use of postoperative radiation therapy leads to excellent long-term local control for the treatment of recurrent pleomorphic adenoma with acceptable late toxicity. Although the incidence of second malignancy was low in this population, continued follow-up is warranted.

KW - Parotid gland

KW - Pleomorphic adenoma

KW - Radiation therapy

KW - Recurrence

UR - http://www.scopus.com/inward/record.url?scp=33750286556&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750286556&partnerID=8YFLogxK

U2 - 10.1016/j.ijrobp.2006.06.036

DO - 10.1016/j.ijrobp.2006.06.036

M3 - Article

C2 - 17145531

AN - SCOPUS:33750286556

VL - 66

SP - 1031

EP - 1035

JO - International Journal of Radiation Oncology Biology Physics

JF - International Journal of Radiation Oncology Biology Physics

SN - 0360-3016

IS - 4

ER -