Recurrent inactivating RASA2 mutations in melanoma

Rand Arafeh, Nouar Qutob, Rafi Emmanuel, Alona Keren-Paz, Jason Madore, Abdel Elkahloun, James S. Wilmott, Jared J. Gartner, Antonella Di Pizio, Sabina Winograd-Katz, Sivasish Sindiri, Ron Rotkopf, Ken Dutton-Regester, Peter Johansson, Antonia L. Pritchard, Nicola Waddell, Victoria K. Hill, Jimmy C. Lin, Yael Hevroni, Steven A. RosenbergJaved Khan, Shifra Ben-Dor, Masha Y. Niv, Igor Ulitsky, Graham J. Mann, Richard A. Scolyer, Nicholas K. Hayward, Yardena Samuels

Research output: Contribution to journalArticle

Abstract

Analysis of 501 melanoma exomes identified RASA2, encoding a RasGAP, as a tumor-suppressor gene mutated in 5% of melanomas. Recurrent loss-of-function mutations in RASA2 were found to increase RAS activation, melanoma cell growth and migration. RASA2 expression was lost in ≥30% of human melanomas and was associated with reduced patient survival. These findings identify RASA2 inactivation as a melanoma driver and highlight the importance of RasGAPs in cancer.

Original languageEnglish (US)
Pages (from-to)1408-1410
Number of pages3
JournalNature Genetics
Volume47
Issue number12
DOIs
StatePublished - Dec 1 2015
Externally publishedYes

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Melanoma
Mutation
Exome
Tumor Suppressor Genes
Cell Movement
Survival
Growth
Neoplasms

ASJC Scopus subject areas

  • Genetics

Cite this

Arafeh, R., Qutob, N., Emmanuel, R., Keren-Paz, A., Madore, J., Elkahloun, A., ... Samuels, Y. (2015). Recurrent inactivating RASA2 mutations in melanoma. Nature Genetics, 47(12), 1408-1410. https://doi.org/10.1038/ng.3427

Recurrent inactivating RASA2 mutations in melanoma. / Arafeh, Rand; Qutob, Nouar; Emmanuel, Rafi; Keren-Paz, Alona; Madore, Jason; Elkahloun, Abdel; Wilmott, James S.; Gartner, Jared J.; Di Pizio, Antonella; Winograd-Katz, Sabina; Sindiri, Sivasish; Rotkopf, Ron; Dutton-Regester, Ken; Johansson, Peter; Pritchard, Antonia L.; Waddell, Nicola; Hill, Victoria K.; Lin, Jimmy C.; Hevroni, Yael; Rosenberg, Steven A.; Khan, Javed; Ben-Dor, Shifra; Niv, Masha Y.; Ulitsky, Igor; Mann, Graham J.; Scolyer, Richard A.; Hayward, Nicholas K.; Samuels, Yardena.

In: Nature Genetics, Vol. 47, No. 12, 01.12.2015, p. 1408-1410.

Research output: Contribution to journalArticle

Arafeh, R, Qutob, N, Emmanuel, R, Keren-Paz, A, Madore, J, Elkahloun, A, Wilmott, JS, Gartner, JJ, Di Pizio, A, Winograd-Katz, S, Sindiri, S, Rotkopf, R, Dutton-Regester, K, Johansson, P, Pritchard, AL, Waddell, N, Hill, VK, Lin, JC, Hevroni, Y, Rosenberg, SA, Khan, J, Ben-Dor, S, Niv, MY, Ulitsky, I, Mann, GJ, Scolyer, RA, Hayward, NK & Samuels, Y 2015, 'Recurrent inactivating RASA2 mutations in melanoma', Nature Genetics, vol. 47, no. 12, pp. 1408-1410. https://doi.org/10.1038/ng.3427
Arafeh R, Qutob N, Emmanuel R, Keren-Paz A, Madore J, Elkahloun A et al. Recurrent inactivating RASA2 mutations in melanoma. Nature Genetics. 2015 Dec 1;47(12):1408-1410. https://doi.org/10.1038/ng.3427
Arafeh, Rand ; Qutob, Nouar ; Emmanuel, Rafi ; Keren-Paz, Alona ; Madore, Jason ; Elkahloun, Abdel ; Wilmott, James S. ; Gartner, Jared J. ; Di Pizio, Antonella ; Winograd-Katz, Sabina ; Sindiri, Sivasish ; Rotkopf, Ron ; Dutton-Regester, Ken ; Johansson, Peter ; Pritchard, Antonia L. ; Waddell, Nicola ; Hill, Victoria K. ; Lin, Jimmy C. ; Hevroni, Yael ; Rosenberg, Steven A. ; Khan, Javed ; Ben-Dor, Shifra ; Niv, Masha Y. ; Ulitsky, Igor ; Mann, Graham J. ; Scolyer, Richard A. ; Hayward, Nicholas K. ; Samuels, Yardena. / Recurrent inactivating RASA2 mutations in melanoma. In: Nature Genetics. 2015 ; Vol. 47, No. 12. pp. 1408-1410.
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