Recurrent chromosome alterations in hepatocellular carcinoma detected by comparative hybridization

Xin Yuan Guan, Yan Fang, Jonathan S T Sham, Dora L W Kwong, Yaqi Zhang, Qiwan Liang, Huimei Li, Heng Zhou, Jeffrey M. Trent

Research output: Contribution to journalArticle

Abstract

Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide and has a very poor prognosis. Fifty primary HCC cases have been analyzed in the present study to explore the association between genomic alteration in primary HCC and clinical features. Several recurrent chromosomal abnormalities were identified in this study. The most frequently detected chromosomal gains involved chromosome arms 1q (33/50 cases, 66%), 8q (24/50 cases, 48%), and 20q (10/50 cases, 20%). High-copy-number amplifications involving lq (4 cases), 8q (3 cases), and 20q (3 cases) were detected, and a minimum overlapping amplified region at 1q12-q22 was identified. The most frequently detected loss of chromosomal material involved 16q (35/50 cases, 70%), 17p (26/50 cases, 52%), 19p (21/50 cases, 42%), 4q (20/50 cases, 40%), 1p (18/50 cases, 36%), 8p (16/50 cases, 32%), and 22q (14/50 cases, 28%). The associations between genomic alterations detected in the present study and clinical features including clinical stage, tumor size, HBV infection, chronic Fiver disease, and liver cirrhosis were explored. Our CGH results suggest that the gain of 20q and deletion of 8p are late genetic alterations in HCC, because the incidence of these alterations was obviously increased in the advanced clinical stages. Another finding showed that loss of 8p and gain of 8q and 20q are associated with tumor size. The recurrent gain and loss of chromosomal regions identified in this study provide candidate regions that may contain oncogenes or tumor suppressor genes respectively involved in HCC development and progression. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish (US)
Pages (from-to)110-116
Number of pages7
JournalGenes Chromosomes and Cancer
Volume29
Issue number2
StatePublished - 2000
Externally publishedYes

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Hepatocellular Carcinoma
Chromosomes
Neoplasms
Tumor Suppressor Genes
Oncogenes
Chromosome Aberrations
Liver Cirrhosis
Chronic Disease
Incidence
Infection

ASJC Scopus subject areas

  • Cancer Research
  • Genetics

Cite this

Guan, X. Y., Fang, Y., Sham, J. S. T., Kwong, D. L. W., Zhang, Y., Liang, Q., ... Trent, J. M. (2000). Recurrent chromosome alterations in hepatocellular carcinoma detected by comparative hybridization. Genes Chromosomes and Cancer, 29(2), 110-116.

Recurrent chromosome alterations in hepatocellular carcinoma detected by comparative hybridization. / Guan, Xin Yuan; Fang, Yan; Sham, Jonathan S T; Kwong, Dora L W; Zhang, Yaqi; Liang, Qiwan; Li, Huimei; Zhou, Heng; Trent, Jeffrey M.

In: Genes Chromosomes and Cancer, Vol. 29, No. 2, 2000, p. 110-116.

Research output: Contribution to journalArticle

Guan, XY, Fang, Y, Sham, JST, Kwong, DLW, Zhang, Y, Liang, Q, Li, H, Zhou, H & Trent, JM 2000, 'Recurrent chromosome alterations in hepatocellular carcinoma detected by comparative hybridization', Genes Chromosomes and Cancer, vol. 29, no. 2, pp. 110-116.
Guan XY, Fang Y, Sham JST, Kwong DLW, Zhang Y, Liang Q et al. Recurrent chromosome alterations in hepatocellular carcinoma detected by comparative hybridization. Genes Chromosomes and Cancer. 2000;29(2):110-116.
Guan, Xin Yuan ; Fang, Yan ; Sham, Jonathan S T ; Kwong, Dora L W ; Zhang, Yaqi ; Liang, Qiwan ; Li, Huimei ; Zhou, Heng ; Trent, Jeffrey M. / Recurrent chromosome alterations in hepatocellular carcinoma detected by comparative hybridization. In: Genes Chromosomes and Cancer. 2000 ; Vol. 29, No. 2. pp. 110-116.
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abstract = "Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide and has a very poor prognosis. Fifty primary HCC cases have been analyzed in the present study to explore the association between genomic alteration in primary HCC and clinical features. Several recurrent chromosomal abnormalities were identified in this study. The most frequently detected chromosomal gains involved chromosome arms 1q (33/50 cases, 66{\%}), 8q (24/50 cases, 48{\%}), and 20q (10/50 cases, 20{\%}). High-copy-number amplifications involving lq (4 cases), 8q (3 cases), and 20q (3 cases) were detected, and a minimum overlapping amplified region at 1q12-q22 was identified. The most frequently detected loss of chromosomal material involved 16q (35/50 cases, 70{\%}), 17p (26/50 cases, 52{\%}), 19p (21/50 cases, 42{\%}), 4q (20/50 cases, 40{\%}), 1p (18/50 cases, 36{\%}), 8p (16/50 cases, 32{\%}), and 22q (14/50 cases, 28{\%}). The associations between genomic alterations detected in the present study and clinical features including clinical stage, tumor size, HBV infection, chronic Fiver disease, and liver cirrhosis were explored. Our CGH results suggest that the gain of 20q and deletion of 8p are late genetic alterations in HCC, because the incidence of these alterations was obviously increased in the advanced clinical stages. Another finding showed that loss of 8p and gain of 8q and 20q are associated with tumor size. The recurrent gain and loss of chromosomal regions identified in this study provide candidate regions that may contain oncogenes or tumor suppressor genes respectively involved in HCC development and progression. (C) 2000 Wiley-Liss, Inc.",
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AU - Zhou, Heng

AU - Trent, Jeffrey M.

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