Recurrence of head and neck cancer after surgery or irradiation: Prospective comparison of 2-deoxy-2-[F-18]fluoro-D-glucose PET and MR imaging diagnoses

Yoshimi Anzai, William R. Carroll, Douglas J. Quint, Carol R. Bradford, Satoshi Minoshima, Gregory T. Wolf, Richard L. Wahl

Research output: Contribution to journalArticle

Abstract

PURPOSE: To evaluate the diagnostic accuracy of positron emission tomography (PET) with administration of 2-deoxy-2-[fluorine-18]fluoro-D- glucose (FDG) relative to that of magnetic resonance (MR) imaging and/or computed tomography (CT) in recurrent head and neck cancers. MATERIALS AND METHODS: Twelve adult patients (mean age, 63 years) with previously treated head and neck cancers and clinical suspicion of recurrence underwent FDG PET and MR imaging and/or CT. All images were blindly and independently interpreted without histopathologic findings (obtained within 1 week of imaging). The level of confidence in image interpretation was graded by using a five-point rating system (0 = definitely no recurrence to 4 = definite recurrence). RESULTS: Recurrence was confirmed in eight patients. With a rating of 4 as a positive finding, FDG PET yielded a sensitivity and specificity of 88% (seven of eight) and 100% (four of four), respectively; MR imaging and/or CT, 25% (two of eight) and 75% (three of four), respectively. Receiver-operating characteristic analysis showed significantly better diagnostic accuracy with FDG PET than with MR imaging and/or CT (area under curve = 0.96 vs 0.55, P <.03). CONCLUSION: These data indicate that PET metabolic imaging, as compared with anatomic methods, has improved diagnostic accuracy for recurrent head and neck cancer.

Original languageEnglish (US)
Pages (from-to)135-141
Number of pages7
JournalRadiology
Volume200
Issue number1
StatePublished - Jul 1996
Externally publishedYes

Fingerprint

Head and Neck Neoplasms
Positron-Emission Tomography
Magnetic Resonance Imaging
Glucose
Recurrence
Tomography
Fluorine
ROC Curve
Area Under Curve
Sensitivity and Specificity

Keywords

  • Emission CT (ECT), comparative studies
  • Gadolinium
  • Head and neck neoplasms, CT
  • Head and neck neoplasms, emission CT (ECT)
  • Head and neck neoplasms, MR

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Anzai, Y., Carroll, W. R., Quint, D. J., Bradford, C. R., Minoshima, S., Wolf, G. T., & Wahl, R. L. (1996). Recurrence of head and neck cancer after surgery or irradiation: Prospective comparison of 2-deoxy-2-[F-18]fluoro-D-glucose PET and MR imaging diagnoses. Radiology, 200(1), 135-141.

Recurrence of head and neck cancer after surgery or irradiation : Prospective comparison of 2-deoxy-2-[F-18]fluoro-D-glucose PET and MR imaging diagnoses. / Anzai, Yoshimi; Carroll, William R.; Quint, Douglas J.; Bradford, Carol R.; Minoshima, Satoshi; Wolf, Gregory T.; Wahl, Richard L.

In: Radiology, Vol. 200, No. 1, 07.1996, p. 135-141.

Research output: Contribution to journalArticle

Anzai, Y, Carroll, WR, Quint, DJ, Bradford, CR, Minoshima, S, Wolf, GT & Wahl, RL 1996, 'Recurrence of head and neck cancer after surgery or irradiation: Prospective comparison of 2-deoxy-2-[F-18]fluoro-D-glucose PET and MR imaging diagnoses', Radiology, vol. 200, no. 1, pp. 135-141.
Anzai, Yoshimi ; Carroll, William R. ; Quint, Douglas J. ; Bradford, Carol R. ; Minoshima, Satoshi ; Wolf, Gregory T. ; Wahl, Richard L. / Recurrence of head and neck cancer after surgery or irradiation : Prospective comparison of 2-deoxy-2-[F-18]fluoro-D-glucose PET and MR imaging diagnoses. In: Radiology. 1996 ; Vol. 200, No. 1. pp. 135-141.
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abstract = "PURPOSE: To evaluate the diagnostic accuracy of positron emission tomography (PET) with administration of 2-deoxy-2-[fluorine-18]fluoro-D- glucose (FDG) relative to that of magnetic resonance (MR) imaging and/or computed tomography (CT) in recurrent head and neck cancers. MATERIALS AND METHODS: Twelve adult patients (mean age, 63 years) with previously treated head and neck cancers and clinical suspicion of recurrence underwent FDG PET and MR imaging and/or CT. All images were blindly and independently interpreted without histopathologic findings (obtained within 1 week of imaging). The level of confidence in image interpretation was graded by using a five-point rating system (0 = definitely no recurrence to 4 = definite recurrence). RESULTS: Recurrence was confirmed in eight patients. With a rating of 4 as a positive finding, FDG PET yielded a sensitivity and specificity of 88{\%} (seven of eight) and 100{\%} (four of four), respectively; MR imaging and/or CT, 25{\%} (two of eight) and 75{\%} (three of four), respectively. Receiver-operating characteristic analysis showed significantly better diagnostic accuracy with FDG PET than with MR imaging and/or CT (area under curve = 0.96 vs 0.55, P <.03). CONCLUSION: These data indicate that PET metabolic imaging, as compared with anatomic methods, has improved diagnostic accuracy for recurrent head and neck cancer.",
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