Recurrence of corneal neovascularization associated with lipid deposition after subconjunctival injection of bevacizumab

Hsiao Sang Chu, Ta Ching Chen, Fung Rong Hu, Wei Li Chen

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To report 7 cases of recurrent corneal neovascularization (NV) and lipid deposition after subconjunctival injection of bevacizumab for the treatment of corneal NV-induced lipid keratopathy. Methods: We conducted a prospective interventional case series that included 20 eyes of chronic lipid keratopathy that received bevacizumab injection for the treatment of corneal NV and lipid deposition, including 7 eyes with recurrent corneal NV and lipid deposition after ceasing treatment. Repeated subconjunctival injections of bevacizumab were performed in 5 patients with recurrence. Penetrating keratoplasty was performed in 1 patient who had severely recurrent lipid deposition. Clinical presentation of corneal NV and lipid deposition, best-corrected visual acuity, and complications after treatments were recorded. Results: Bevacizumab inhibited corneal NV and lipid depositions in 19 patients. Seven of the 20 patients (35%) had different patterns of recurrence of corneal NV/lipid deposition 6 to 15 months after discontinuing treatment. Five of the 7 patients in whom corneal NV/lipid deposition was recurrent received another course of repeated bevacizumab treatments. Three eyes had partial response to the second course of treatment. Two eyes had too short re-treatment course to have conclusions. One patient who received penetrating keratoplasty had successful result after surgery. Conclusions: Corneal NV and lipid deposition may recur after ceasing the subconjunctival bevacizumab injections for lipid keratopathy. Some patients respond at least partially to repeated injections.

Original languageEnglish (US)
Pages (from-to)1446-1453
Number of pages8
JournalCornea
Volume32
Issue number11
DOIs
StatePublished - Nov 1 2013

Keywords

  • Corneal neovascularization
  • bevacizumab
  • lipid keratopathy

ASJC Scopus subject areas

  • Ophthalmology

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