Rectosigmoid resection at the time of primary cytoreduction for advanced ovarian cancer. A multi-center analysis of surgical and oncological outcomes

Michele Peiretti, Robert E. Bristow, Ignacio Zapardiel, Melissa Gerardi, Vanna Zanagnolo, Roberto Biffi, Fabio Landoni, Luca Bocciolone, Giovanni Damiano Aletti, Angelo Maggioni

Research output: Contribution to journalArticle

Abstract

Objective: The aim of the study was to determine the impact of rectosigmoid resection, at the time of primary cytoreductive surgery, on morbidity and survival of patients with advanced ovarian cancer. Methods: We performed a retrospective medical chart review of patients who underwent rectosigmoid resection for ovarian, tubal and peritoneal cancers between 1998 and 2008 at the IEO in Milan and JHMI in Baltimore. Perioperative and follow-up data were collected. Results: A total of 238 patients were identified; 180 (75%) had stages IIC-IIIC and 58 (25%) had stage IV. Complete cytoreduction was achieved in 41% of the cases. Stapled coloproctostomy was performed in 98% while hand sewn in only 2%; a protective ileostomy and colostomy were necessary (constructed) in 2 (0.8%) and 5 (2%) cases respectively. The complications associated to rectosigmoid resection were anastomotic leakage in 7 (3%) patients and pelvic abscess in 9 (3.7%). Fifty percent of patients recurred during the study period, but only 5% of them showed a relapse at the level of the pelvis whereas 8% presented with abdominal recurrence associated with pelvic disease as well. The median overall survival time among patients with complete cytoreduction was 72 months compared with 42 months among the rest of patients (p = 0.002). Conclusions: Rectosigmoid colectomy may significantly contribute to achieve a complete primary cytoreduction for advanced stage ovarian, tubal and peritoneal cancers. Pelvic complete debulking accomplished by rectosigmoid resection could be associated with a lower rate of pelvic recurrence as well.

Original languageEnglish (US)
Pages (from-to)220-223
Number of pages4
JournalGynecologic Oncology
Volume126
Issue number2
DOIs
StatePublished - Aug 2012
Externally publishedYes

Fingerprint

Ovarian Neoplasms
Recurrence
Ileostomy
Baltimore
Anastomotic Leak
Colostomy
Survival
Colectomy
Pelvis
Abscess
Neoplasms
Hand
Morbidity

Keywords

  • Bowel resection
  • Cytoreduction
  • Ovarian cancer

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Oncology

Cite this

Rectosigmoid resection at the time of primary cytoreduction for advanced ovarian cancer. A multi-center analysis of surgical and oncological outcomes. / Peiretti, Michele; Bristow, Robert E.; Zapardiel, Ignacio; Gerardi, Melissa; Zanagnolo, Vanna; Biffi, Roberto; Landoni, Fabio; Bocciolone, Luca; Aletti, Giovanni Damiano; Maggioni, Angelo.

In: Gynecologic Oncology, Vol. 126, No. 2, 08.2012, p. 220-223.

Research output: Contribution to journalArticle

Peiretti, M, Bristow, RE, Zapardiel, I, Gerardi, M, Zanagnolo, V, Biffi, R, Landoni, F, Bocciolone, L, Aletti, GD & Maggioni, A 2012, 'Rectosigmoid resection at the time of primary cytoreduction for advanced ovarian cancer. A multi-center analysis of surgical and oncological outcomes', Gynecologic Oncology, vol. 126, no. 2, pp. 220-223. https://doi.org/10.1016/j.ygyno.2012.04.030
Peiretti, Michele ; Bristow, Robert E. ; Zapardiel, Ignacio ; Gerardi, Melissa ; Zanagnolo, Vanna ; Biffi, Roberto ; Landoni, Fabio ; Bocciolone, Luca ; Aletti, Giovanni Damiano ; Maggioni, Angelo. / Rectosigmoid resection at the time of primary cytoreduction for advanced ovarian cancer. A multi-center analysis of surgical and oncological outcomes. In: Gynecologic Oncology. 2012 ; Vol. 126, No. 2. pp. 220-223.
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AU - Gerardi, Melissa

AU - Zanagnolo, Vanna

AU - Biffi, Roberto

AU - Landoni, Fabio

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AU - Aletti, Giovanni Damiano

AU - Maggioni, Angelo

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