Recruitment in the Hypertension Prevention Trial

N. O. Borhani, J. Tonascia, D. G. Schlundt, R. J. Prineas, J. L. Jefferys

Research output: Chapter in Book/Report/Conference proceedingChapter

37 Scopus citations


The Hypertension Prevention Trial (HPT) was a randomized, controlled, multicenter (four clinics, four resource centers) trial designed to test the feasibility of achieving and sustaining dietary changes in the intake of calories, sodium, and potassium and to assess the effect of those changes on blood pressure in a normotensive population. The trial involved 841 men and women (plus a test cohort of 78) who, at the first baseline (BL) examination were in the age range of 25-49 years and had diastolic blood pressure (DBP) ≥76 but <100 mm Hg (average of two readings), and at the examination prior to randomization (BL 2), had DBP ≥78 but <90 mm Hg (also averaged). Participants were randomly assigned to a control treatment group (no dietary counseling) or to one of four dietary treatment groups involving counseling designed to reduce calorie intake, reduce sodium intake, reduce sodium and calorie intake, and reduce sodium and increase potassium intake. This chapter describes the process of recruiting participants for the trial. Methods used to identify and contact study participants are presented. Details of the steps involved in the recruitment process and strategies for reducing costs are discussed.

Original languageEnglish (US)
Title of host publicationControlled Clinical Trials
Edition3 SUPPL.
StatePublished - 1989


  • Behavior modification
  • Blood pressure
  • Clinical trial
  • Dietary trial
  • Enrollment
  • Hypertension
  • Primary prevention trial
  • Recruitment
  • Recruitment costs
  • Sample size
  • Screening

ASJC Scopus subject areas

  • Pharmacology


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