Recreational drug use and T lymphocyte subpopulations in HIV-uninfected and HIV-infected men

Chun Chao, Lisa Paula Jacobson, Donald Tashkin, Otoniel Martínez-Maza, Michael D. Roth, Joseph Bernard Margolick, Joan S. Chmiel, Charles Rinaldo, Zuo Feng Zhang, Roger Detels

Research output: Contribution to journalArticle

Abstract

The effects of recreational drugs on CD4 and CD8 T cells in humans are not well understood. We conducted a longitudinal analysis of men who have sex with men (MSM) enrolled in the Multicenter AIDS Cohort Study (MACS) to define associations between self-reported use of marijuana, cocaine, poppers and amphetamines, and CD4 and CD8 T cell parameters in both HIV-uninfected and HIV-infected MSM. For the HIV-infected MSM, we used clinical and laboratory data collected semiannually before 1996 to avoid potential effects of antiretroviral treatment. A regression model that allowed random intercepts and slopes as well as autoregressive covariance structure for within subject errors was used. Potential confounders adjusted for included length of follow-up, demographics, tobacco smoking, alcohol use, risky sexual behaviors, history of sexually transmitted infections, and antiviral therapy. We found no clinically meaningful associations between use of marijuana, cocaine, poppers, or amphetamines and CD4 and CD8 T cell counts, percentages, or rates of change in either HIV-uninfected or -infected men. The regression coefficients were of minimum magnitude despite some reaching statistical significance. No threshold effect was detected for frequent (at least weekly) or continuous substance use in the previous year. These results indicate that use of these substances does not adversely affect the numbers and percentages of circulating CD4 or CD8 T cells in either HIV-uninfected or -infected MSM.

Original languageEnglish (US)
Pages (from-to)165-171
Number of pages7
JournalDrug and Alcohol Dependence
Volume94
Issue number1-3
DOIs
StatePublished - Apr 1 2008

Fingerprint

T-cells
Lymphocyte Subsets
Street Drugs
drug use
HIV
T-Lymphocytes
Amphetamines
Cannabis
Cocaine
regression
statistical significance
nicotine
Tobacco
smoking
AIDS
alcohol
drug
Antiviral Agents
Sexually Transmitted Diseases
Sexual Behavior

Keywords

  • Cocaine
  • HIV infection
  • Marijuana
  • Poppers
  • Recreational drug use
  • T cells

ASJC Scopus subject areas

  • Medicine(all)
  • Behavioral Neuroscience
  • Toxicology
  • Health(social science)

Cite this

Recreational drug use and T lymphocyte subpopulations in HIV-uninfected and HIV-infected men. / Chao, Chun; Jacobson, Lisa Paula; Tashkin, Donald; Martínez-Maza, Otoniel; Roth, Michael D.; Margolick, Joseph Bernard; Chmiel, Joan S.; Rinaldo, Charles; Zhang, Zuo Feng; Detels, Roger.

In: Drug and Alcohol Dependence, Vol. 94, No. 1-3, 01.04.2008, p. 165-171.

Research output: Contribution to journalArticle

Chao, C, Jacobson, LP, Tashkin, D, Martínez-Maza, O, Roth, MD, Margolick, JB, Chmiel, JS, Rinaldo, C, Zhang, ZF & Detels, R 2008, 'Recreational drug use and T lymphocyte subpopulations in HIV-uninfected and HIV-infected men', Drug and Alcohol Dependence, vol. 94, no. 1-3, pp. 165-171. https://doi.org/10.1016/j.drugalcdep.2007.11.010
Chao, Chun ; Jacobson, Lisa Paula ; Tashkin, Donald ; Martínez-Maza, Otoniel ; Roth, Michael D. ; Margolick, Joseph Bernard ; Chmiel, Joan S. ; Rinaldo, Charles ; Zhang, Zuo Feng ; Detels, Roger. / Recreational drug use and T lymphocyte subpopulations in HIV-uninfected and HIV-infected men. In: Drug and Alcohol Dependence. 2008 ; Vol. 94, No. 1-3. pp. 165-171.
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