Recreational drug use and risk of Kaposi's Sarcoma in HIV- and HHV-8-coinfected homosexual men

Chun Chao, Lisa P. Jacobson, Frank J. Jenkins, Donald Tashkin, Otoniel Martínez-Maza, Michael D. Roth, Leslie Ng, Joseph B. Margolick, Joan S. Chmiel, Zuo Feng Zhang, Roger Detels

Research output: Contribution to journalArticle

Abstract

Experimental data suggested that exposure to recreational drugs might adversely affect antitumor immunity, which led us to examine the hypothesis that use of marijuana, cocaine, poppers, and amphetamines might increase the risk of Kaposi's Sarcoma (KS) in HIV- and HHV-8-coinfected homosexual men. We analyzed data prospectively collected from the Multicenter AIDS Cohort Study (MACS) between 1984 and 2002. Among the 1335 HIV- and HHV-8-coinfected white men, 401 KS cases were identified. Multivariable Cox regression models were used to estimate the effects of time-varying recreational drug use on KS risk adjusting for potential confounders. The effects of both recent use (6 months prior) of recreational drugs and lagged exposure (i.e., use from 3 and 5 years prior) were examined. We did not observe any clear association with KS for recent use of any of the four drugs. In the analyses using lagged exposures, KS risk was associated with use of poppers 3-5 years prior [hazard ratio (HR) 3 years prior = 1.27, 95% CI (0.97-1.67), HR5 years prior = 1.46 (1.01-2.13)]. However, no clear dose-response relationship was observed. These findings do not support a biological association between use of these substances and KS development in HIV- and HHV-8-coinfected homosexual men.

Original languageEnglish (US)
Pages (from-to)149-156
Number of pages8
JournalAIDS research and human retroviruses
Volume25
Issue number2
DOIs
StatePublished - Feb 1 2009

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

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  • Cite this

    Chao, C., Jacobson, L. P., Jenkins, F. J., Tashkin, D., Martínez-Maza, O., Roth, M. D., Ng, L., Margolick, J. B., Chmiel, J. S., Zhang, Z. F., & Detels, R. (2009). Recreational drug use and risk of Kaposi's Sarcoma in HIV- and HHV-8-coinfected homosexual men. AIDS research and human retroviruses, 25(2), 149-156. https://doi.org/10.1089/aid.2008.0196