TY - JOUR
T1 - Recovery of left ventricular function in acute nonischemic congestive cardiomyopathy
AU - Cross, Andrew M.
AU - Steenbergen, Charles
AU - Higginbotham, Michael B.
N1 - Funding Information:
From the bDepartment of Medicine, Division of Cardiology and the Department of Pathology, Duke University Medical Center, Durham; and the aDepartment of Internal Medicine, Division of Cardiology, University of Kentucky Medical Center, Lexington. Supported in part by National Research Service Award grant HL07101-17 from the National Institutes of Health. Received for publication Nov. 18, 1993; accepted March 7, 1994. Reprint requests: Andrew M. Cross, Jr., MD, Division of Cardiology, Room MN 670 UKMC, 800 Rose St., Lexington, KY 40536-0084. Copyright ® 1995 by Mosby-Year Book, Inc. 0002-8703/95/$3.00 + 0 4/1/59139
PY - 1995/1
Y1 - 1995/1
N2 - The extent and time course of recovery of left ventricular function were investigated in 29 patients with no previous symptoms who had acute nonischemic congestive cardiomyopathy and left ventricular ejection fraction of 0.22 ± 0.07. Improvement in left ventricular ejection fraction by at least 0.05 was observed in 24 of the 29 patients and was achieved within 6 months after the initial evaluation. Progressive improvement was seen, with a maximum ejection fraction of 0.45 ± 0.17 being achieved within approximately 18 months. The degree of ejection fraction recovery was not related to the initial clinical or hemodynamic variables. However, the extent of fibrosis detected on endomyocardial biopsy correlated inversely with subsequent changes in ejection fraction (r = -0.65, p = 0.0003). Thus significant recovery is likely after an acute episode of nonischemic cardiomyopathy and may be progressive during the first year. Recovery is related to the extent of myocardial fibrosis detected on endomyocardial biopsy but cannot be predicted from the initial clinical or hemodynamic presentation.
AB - The extent and time course of recovery of left ventricular function were investigated in 29 patients with no previous symptoms who had acute nonischemic congestive cardiomyopathy and left ventricular ejection fraction of 0.22 ± 0.07. Improvement in left ventricular ejection fraction by at least 0.05 was observed in 24 of the 29 patients and was achieved within 6 months after the initial evaluation. Progressive improvement was seen, with a maximum ejection fraction of 0.45 ± 0.17 being achieved within approximately 18 months. The degree of ejection fraction recovery was not related to the initial clinical or hemodynamic variables. However, the extent of fibrosis detected on endomyocardial biopsy correlated inversely with subsequent changes in ejection fraction (r = -0.65, p = 0.0003). Thus significant recovery is likely after an acute episode of nonischemic cardiomyopathy and may be progressive during the first year. Recovery is related to the extent of myocardial fibrosis detected on endomyocardial biopsy but cannot be predicted from the initial clinical or hemodynamic presentation.
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U2 - 10.1016/0002-8703(95)90038-1
DO - 10.1016/0002-8703(95)90038-1
M3 - Article
C2 - 7817920
AN - SCOPUS:0028799573
SN - 0002-8703
VL - 129
SP - 24
EP - 30
JO - American heart journal
JF - American heart journal
IS - 1
ER -