Recovery of Kidney Function After Acute Kidney Injury in the Elderly: A Systematic Review and Meta-analysis

Roland Schmitt, Steven Coca, Mehmet Kanbay, Mary E. Tinetti, Lloyd G. Cantley, Chirag Parikh

Research output: Contribution to journalArticle

Abstract

Background: The prevalence of elderly individuals continues to increase over time, as does the incidence of acute kidney injury (AKI). However, it is not known whether age is an important prognostic predictor for renal recovery after an episode of AKI. Study Design: Systematic review of MEDLINE and EMBASE databases and meta-analysis of pooled data using random-effect models. Setting & Population: Adults with AKI, not including kidney transplant recipients. Selection Criteria for Studies: Studies published in English between 2000 and 2007 were eligible for this analysis if they met the following inclusion criteria: (1) clear definition of AKI and recovery of kidney function, (2) assessment of kidney function recovery as the primary or secondary outcome, and (3) participant age reported. We contacted the investigators of studies and requested data for recovery of kidney function by patient age. Predictor: Patient age of 65 years and older and younger than 65 years. Outcomes: Recovery of kidney function defined as independence from dialysis therapy, decrease in serum creatinine level to less than a defined threshold, or return to baseline kidney function. Results: We obtained data for recovery of kidney function by age from 17 studies of patients with AKI. Overall, 31.3% of surviving elderly patients did not recover kidney function compared with 26% of younger patients (pooled relative risk, 1.28, 95% confidence interval, 1.06 to 1.55; P < 0.05). The increased risk of nonrecovery in the elderly remained greater in several subgroups examined through sensitivity analyses, including those stratified by type of dialysis support, time of assessment of recovery (short versus long term), and definition of renal recovery. Limitations: There was significant heterogeneity among studies with respect to comorbid factors, definition of AKI, and study design. Conclusions: There is impaired recovery of kidney function after AKI in aged individuals. Future studies should be cognizant of "age" as a potential effect modifier in the prognosis after AKI, and clinical trials should focus on improving outcomes in the elderly cohort.

Original languageEnglish (US)
Pages (from-to)262-271
Number of pages10
JournalAmerican Journal of Kidney Diseases
Volume52
Issue number2
DOIs
StatePublished - Aug 1 2008

Fingerprint

Recovery of Function
Acute Kidney Injury
Meta-Analysis
Kidney
Dialysis
MEDLINE
Patient Selection
Creatinine
Research Personnel
Clinical Trials
Databases
Confidence Intervals

Keywords

  • Acute kidney injury
  • aging
  • functional recovery
  • prognosis
  • serum creatinine

ASJC Scopus subject areas

  • Nephrology

Cite this

Recovery of Kidney Function After Acute Kidney Injury in the Elderly : A Systematic Review and Meta-analysis. / Schmitt, Roland; Coca, Steven; Kanbay, Mehmet; Tinetti, Mary E.; Cantley, Lloyd G.; Parikh, Chirag.

In: American Journal of Kidney Diseases, Vol. 52, No. 2, 01.08.2008, p. 262-271.

Research output: Contribution to journalArticle

Schmitt, Roland ; Coca, Steven ; Kanbay, Mehmet ; Tinetti, Mary E. ; Cantley, Lloyd G. ; Parikh, Chirag. / Recovery of Kidney Function After Acute Kidney Injury in the Elderly : A Systematic Review and Meta-analysis. In: American Journal of Kidney Diseases. 2008 ; Vol. 52, No. 2. pp. 262-271.
@article{33fc22437b8249e1bcd399991641a85c,
title = "Recovery of Kidney Function After Acute Kidney Injury in the Elderly: A Systematic Review and Meta-analysis",
abstract = "Background: The prevalence of elderly individuals continues to increase over time, as does the incidence of acute kidney injury (AKI). However, it is not known whether age is an important prognostic predictor for renal recovery after an episode of AKI. Study Design: Systematic review of MEDLINE and EMBASE databases and meta-analysis of pooled data using random-effect models. Setting & Population: Adults with AKI, not including kidney transplant recipients. Selection Criteria for Studies: Studies published in English between 2000 and 2007 were eligible for this analysis if they met the following inclusion criteria: (1) clear definition of AKI and recovery of kidney function, (2) assessment of kidney function recovery as the primary or secondary outcome, and (3) participant age reported. We contacted the investigators of studies and requested data for recovery of kidney function by patient age. Predictor: Patient age of 65 years and older and younger than 65 years. Outcomes: Recovery of kidney function defined as independence from dialysis therapy, decrease in serum creatinine level to less than a defined threshold, or return to baseline kidney function. Results: We obtained data for recovery of kidney function by age from 17 studies of patients with AKI. Overall, 31.3{\%} of surviving elderly patients did not recover kidney function compared with 26{\%} of younger patients (pooled relative risk, 1.28, 95{\%} confidence interval, 1.06 to 1.55; P < 0.05). The increased risk of nonrecovery in the elderly remained greater in several subgroups examined through sensitivity analyses, including those stratified by type of dialysis support, time of assessment of recovery (short versus long term), and definition of renal recovery. Limitations: There was significant heterogeneity among studies with respect to comorbid factors, definition of AKI, and study design. Conclusions: There is impaired recovery of kidney function after AKI in aged individuals. Future studies should be cognizant of {"}age{"} as a potential effect modifier in the prognosis after AKI, and clinical trials should focus on improving outcomes in the elderly cohort.",
keywords = "Acute kidney injury, aging, functional recovery, prognosis, serum creatinine",
author = "Roland Schmitt and Steven Coca and Mehmet Kanbay and Tinetti, {Mary E.} and Cantley, {Lloyd G.} and Chirag Parikh",
year = "2008",
month = "8",
day = "1",
doi = "10.1053/j.ajkd.2008.03.005",
language = "English (US)",
volume = "52",
pages = "262--271",
journal = "American Journal of Kidney Diseases",
issn = "0272-6386",
publisher = "W.B. Saunders Ltd",
number = "2",

}

TY - JOUR

T1 - Recovery of Kidney Function After Acute Kidney Injury in the Elderly

T2 - A Systematic Review and Meta-analysis

AU - Schmitt, Roland

AU - Coca, Steven

AU - Kanbay, Mehmet

AU - Tinetti, Mary E.

AU - Cantley, Lloyd G.

AU - Parikh, Chirag

PY - 2008/8/1

Y1 - 2008/8/1

N2 - Background: The prevalence of elderly individuals continues to increase over time, as does the incidence of acute kidney injury (AKI). However, it is not known whether age is an important prognostic predictor for renal recovery after an episode of AKI. Study Design: Systematic review of MEDLINE and EMBASE databases and meta-analysis of pooled data using random-effect models. Setting & Population: Adults with AKI, not including kidney transplant recipients. Selection Criteria for Studies: Studies published in English between 2000 and 2007 were eligible for this analysis if they met the following inclusion criteria: (1) clear definition of AKI and recovery of kidney function, (2) assessment of kidney function recovery as the primary or secondary outcome, and (3) participant age reported. We contacted the investigators of studies and requested data for recovery of kidney function by patient age. Predictor: Patient age of 65 years and older and younger than 65 years. Outcomes: Recovery of kidney function defined as independence from dialysis therapy, decrease in serum creatinine level to less than a defined threshold, or return to baseline kidney function. Results: We obtained data for recovery of kidney function by age from 17 studies of patients with AKI. Overall, 31.3% of surviving elderly patients did not recover kidney function compared with 26% of younger patients (pooled relative risk, 1.28, 95% confidence interval, 1.06 to 1.55; P < 0.05). The increased risk of nonrecovery in the elderly remained greater in several subgroups examined through sensitivity analyses, including those stratified by type of dialysis support, time of assessment of recovery (short versus long term), and definition of renal recovery. Limitations: There was significant heterogeneity among studies with respect to comorbid factors, definition of AKI, and study design. Conclusions: There is impaired recovery of kidney function after AKI in aged individuals. Future studies should be cognizant of "age" as a potential effect modifier in the prognosis after AKI, and clinical trials should focus on improving outcomes in the elderly cohort.

AB - Background: The prevalence of elderly individuals continues to increase over time, as does the incidence of acute kidney injury (AKI). However, it is not known whether age is an important prognostic predictor for renal recovery after an episode of AKI. Study Design: Systematic review of MEDLINE and EMBASE databases and meta-analysis of pooled data using random-effect models. Setting & Population: Adults with AKI, not including kidney transplant recipients. Selection Criteria for Studies: Studies published in English between 2000 and 2007 were eligible for this analysis if they met the following inclusion criteria: (1) clear definition of AKI and recovery of kidney function, (2) assessment of kidney function recovery as the primary or secondary outcome, and (3) participant age reported. We contacted the investigators of studies and requested data for recovery of kidney function by patient age. Predictor: Patient age of 65 years and older and younger than 65 years. Outcomes: Recovery of kidney function defined as independence from dialysis therapy, decrease in serum creatinine level to less than a defined threshold, or return to baseline kidney function. Results: We obtained data for recovery of kidney function by age from 17 studies of patients with AKI. Overall, 31.3% of surviving elderly patients did not recover kidney function compared with 26% of younger patients (pooled relative risk, 1.28, 95% confidence interval, 1.06 to 1.55; P < 0.05). The increased risk of nonrecovery in the elderly remained greater in several subgroups examined through sensitivity analyses, including those stratified by type of dialysis support, time of assessment of recovery (short versus long term), and definition of renal recovery. Limitations: There was significant heterogeneity among studies with respect to comorbid factors, definition of AKI, and study design. Conclusions: There is impaired recovery of kidney function after AKI in aged individuals. Future studies should be cognizant of "age" as a potential effect modifier in the prognosis after AKI, and clinical trials should focus on improving outcomes in the elderly cohort.

KW - Acute kidney injury

KW - aging

KW - functional recovery

KW - prognosis

KW - serum creatinine

UR - http://www.scopus.com/inward/record.url?scp=47149094501&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=47149094501&partnerID=8YFLogxK

U2 - 10.1053/j.ajkd.2008.03.005

DO - 10.1053/j.ajkd.2008.03.005

M3 - Article

C2 - 18511164

AN - SCOPUS:47149094501

VL - 52

SP - 262

EP - 271

JO - American Journal of Kidney Diseases

JF - American Journal of Kidney Diseases

SN - 0272-6386

IS - 2

ER -