Recovery of functional memory T cells in lung transplant recipients following induction therapy with alemtuzumab

A. Zeevi, S. Husain, K. J. Spichty, K. Raza, J. B. Woodcock, D. Zaldonis, L. M. Carruth, R. J. Kowalski, J. A. Britz, K. R. McCurry

Research output: Contribution to journalArticle

Abstract

Profound T-cell depletion with the monoclonal antibody alemtuzumab facilitates reduced maintenance immunosuppression in abdominal and lung transplantation. While the phenotype of the post-depletional T cells has been characterized, little is known about their function. In the present study, global and CMV-specific T-cell function was assessed longitudinally in 23 lung transplant (LTx) recipients using T-cell assays (ImmuKnow® and T Cell Memory™, Cylex, Columbia, MD) during the first year posttransplant after induction therapy. Recovery of mitogen responses were seen at 2 weeks posttransplantation (65%PHA; 58% Con A), despite the low number of circulating T cells (

Original languageEnglish (US)
Pages (from-to)471-475
Number of pages5
JournalAmerican Journal of Transplantation
Volume7
Issue number2
DOIs
Publication statusPublished - Feb 2007
Externally publishedYes

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Keywords

  • CMV
  • Depletion
  • Memory
  • T cell
  • Transplantation

ASJC Scopus subject areas

  • Immunology

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