Recovery of functional memory T cells in lung transplant recipients following induction therapy with alemtuzumab

A. Zeevi, S. Husain, K. J. Spichty, K. Raza, J. B. Woodcock, D. Zaldonis, L. M. Carruth, R. J. Kowalski, J. A. Britz, K. R. McCurry

Research output: Contribution to journalArticle

Abstract

Profound T-cell depletion with the monoclonal antibody alemtuzumab facilitates reduced maintenance immunosuppression in abdominal and lung transplantation. While the phenotype of the post-depletional T cells has been characterized, little is known about their function. In the present study, global and CMV-specific T-cell function was assessed longitudinally in 23 lung transplant (LTx) recipients using T-cell assays (ImmuKnow® and T Cell Memory™, Cylex, Columbia, MD) during the first year posttransplant after induction therapy. Recovery of mitogen responses were seen at 2 weeks posttransplantation (65%PHA; 58% Con A), despite the low number of circulating T cells (

Original languageEnglish (US)
Pages (from-to)471-475
Number of pages5
JournalAmerican Journal of Transplantation
Volume7
Issue number2
DOIs
StatePublished - Feb 2007
Externally publishedYes

Fingerprint

T-Lymphocytes
Lung
Therapeutics
Lung Transplantation
Mitogens
Immunosuppression
Transplant Recipients
alemtuzumab
Monoclonal Antibodies
Maintenance
Phenotype

Keywords

  • CMV
  • Depletion
  • Memory
  • T cell
  • Transplantation

ASJC Scopus subject areas

  • Immunology

Cite this

Recovery of functional memory T cells in lung transplant recipients following induction therapy with alemtuzumab. / Zeevi, A.; Husain, S.; Spichty, K. J.; Raza, K.; Woodcock, J. B.; Zaldonis, D.; Carruth, L. M.; Kowalski, R. J.; Britz, J. A.; McCurry, K. R.

In: American Journal of Transplantation, Vol. 7, No. 2, 02.2007, p. 471-475.

Research output: Contribution to journalArticle

Zeevi, A, Husain, S, Spichty, KJ, Raza, K, Woodcock, JB, Zaldonis, D, Carruth, LM, Kowalski, RJ, Britz, JA & McCurry, KR 2007, 'Recovery of functional memory T cells in lung transplant recipients following induction therapy with alemtuzumab', American Journal of Transplantation, vol. 7, no. 2, pp. 471-475. https://doi.org/10.1111/j.1600-6143.2006.01641.x
Zeevi, A. ; Husain, S. ; Spichty, K. J. ; Raza, K. ; Woodcock, J. B. ; Zaldonis, D. ; Carruth, L. M. ; Kowalski, R. J. ; Britz, J. A. ; McCurry, K. R. / Recovery of functional memory T cells in lung transplant recipients following induction therapy with alemtuzumab. In: American Journal of Transplantation. 2007 ; Vol. 7, No. 2. pp. 471-475.
@article{fc853e5db66b4938afd0c620699938a0,
title = "Recovery of functional memory T cells in lung transplant recipients following induction therapy with alemtuzumab",
abstract = "Profound T-cell depletion with the monoclonal antibody alemtuzumab facilitates reduced maintenance immunosuppression in abdominal and lung transplantation. While the phenotype of the post-depletional T cells has been characterized, little is known about their function. In the present study, global and CMV-specific T-cell function was assessed longitudinally in 23 lung transplant (LTx) recipients using T-cell assays (ImmuKnow{\circledR} and T Cell Memory™, Cylex, Columbia, MD) during the first year posttransplant after induction therapy. Recovery of mitogen responses were seen at 2 weeks posttransplantation (65{\%}PHA; 58{\%} Con A), despite the low number of circulating T cells (",
keywords = "CMV, Depletion, Memory, T cell, Transplantation",
author = "A. Zeevi and S. Husain and Spichty, {K. J.} and K. Raza and Woodcock, {J. B.} and D. Zaldonis and Carruth, {L. M.} and Kowalski, {R. J.} and Britz, {J. A.} and McCurry, {K. R.}",
year = "2007",
month = "2",
doi = "10.1111/j.1600-6143.2006.01641.x",
language = "English (US)",
volume = "7",
pages = "471--475",
journal = "American Journal of Transplantation",
issn = "1600-6135",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Recovery of functional memory T cells in lung transplant recipients following induction therapy with alemtuzumab

AU - Zeevi, A.

AU - Husain, S.

AU - Spichty, K. J.

AU - Raza, K.

AU - Woodcock, J. B.

AU - Zaldonis, D.

AU - Carruth, L. M.

AU - Kowalski, R. J.

AU - Britz, J. A.

AU - McCurry, K. R.

PY - 2007/2

Y1 - 2007/2

N2 - Profound T-cell depletion with the monoclonal antibody alemtuzumab facilitates reduced maintenance immunosuppression in abdominal and lung transplantation. While the phenotype of the post-depletional T cells has been characterized, little is known about their function. In the present study, global and CMV-specific T-cell function was assessed longitudinally in 23 lung transplant (LTx) recipients using T-cell assays (ImmuKnow® and T Cell Memory™, Cylex, Columbia, MD) during the first year posttransplant after induction therapy. Recovery of mitogen responses were seen at 2 weeks posttransplantation (65%PHA; 58% Con A), despite the low number of circulating T cells (

AB - Profound T-cell depletion with the monoclonal antibody alemtuzumab facilitates reduced maintenance immunosuppression in abdominal and lung transplantation. While the phenotype of the post-depletional T cells has been characterized, little is known about their function. In the present study, global and CMV-specific T-cell function was assessed longitudinally in 23 lung transplant (LTx) recipients using T-cell assays (ImmuKnow® and T Cell Memory™, Cylex, Columbia, MD) during the first year posttransplant after induction therapy. Recovery of mitogen responses were seen at 2 weeks posttransplantation (65%PHA; 58% Con A), despite the low number of circulating T cells (

KW - CMV

KW - Depletion

KW - Memory

KW - T cell

KW - Transplantation

UR - http://www.scopus.com/inward/record.url?scp=33846240793&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846240793&partnerID=8YFLogxK

U2 - 10.1111/j.1600-6143.2006.01641.x

DO - 10.1111/j.1600-6143.2006.01641.x

M3 - Article

C2 - 17283491

AN - SCOPUS:33846240793

VL - 7

SP - 471

EP - 475

JO - American Journal of Transplantation

JF - American Journal of Transplantation

SN - 1600-6135

IS - 2

ER -