Recovery from viral encephalomyelitis

Immune-mediated noncytolytic virus clearance from neurons

Research output: Contribution to journalArticle

Abstract

Viral encephalomyelitis is caused by virus infections of neurons in the brain and spinal cord. Recovery is dependent on immune-mediated control and clearance of virus from these terminally differentiated essential cells. Preservation of neuronal function is essential for prevention of neurologic sequelae such as paralysis, seizures and cognitive deficits. Using the model system of Sindbis virus-induced encephalomyelitis in mice, we have shown that immune-mediated clearance of infectious virus from neurons is a noncytolytic process. The major effectors are antibody to the E2 surface glycoprotein produced by B cells, and interferon-γ produced by T cells. These effectors work in synergy, but neuronal populations differ in their responses to each. Virus is least likely to be cleared from brain neurons and most likely to be cleared from motor neurons in the cervical and thoracic regions of the spinal cord. Because the infected neurons are not eliminated, viral RNA persists and long-term control is needed to prevent virus reactivation. Virus-specific antibody-secreting cells residing in the nervous system after recovery from infection are likely to be important for long-term control.

Original languageEnglish (US)
Pages (from-to)123-133
Number of pages11
JournalImmunologic Research
Volume47
Issue number1-3
DOIs
StatePublished - Jul 2010

Fingerprint

Encephalomyelitis
Viruses
Neurons
Nervous System
Spinal Cord
Sindbis Virus
Antibody-Producing Cells
Membrane Glycoproteins
Brain
Viral RNA
Motor Neurons
Virus Diseases
Paralysis
Interferons
Seizures
B-Lymphocytes
Thorax
T-Lymphocytes
Antibodies
Infection

Keywords

  • Alphavirus encephalitis
  • Antiviral antibody
  • Interferon-γ
  • Neuronal virus infection
  • Noncytolytic virus clearance

ASJC Scopus subject areas

  • Immunology
  • Medicine(all)

Cite this

Recovery from viral encephalomyelitis : Immune-mediated noncytolytic virus clearance from neurons. / Griffin, Diane.

In: Immunologic Research, Vol. 47, No. 1-3, 07.2010, p. 123-133.

Research output: Contribution to journalArticle

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