Recordings of abnormal activity in patients with deafferentation and central pain

Teruyasu Hirayama, Jonathan O. Dostrovsky, John Gorecki, Ronald R. Tasker, Fredrick A. Lenz

Research output: Contribution to journalArticlepeer-review

Abstract

We have performed a single-unit analysis of the spontaneous activity of cells in 9 patients with central and deafferentation pain and 4 patients without pain. These studies have concentrated on the analysis of cells firing in bursts, which are particularly prevalent in pain patients. These cells were found to fire typically at interspike intervals of 1–2 ms and interburst intervals of 50 ms. Such cells occurred throughout nucleus ventralis caudalis, nucleus ventrocaudalis parvocellularis and possibly nucleus ventralis intermedius and are different in terms of firing characteristics and locations from bursting cells found in non-pain patients.

Original languageEnglish (US)
Pages (from-to)120-126
Number of pages7
JournalStereotactic and Functional Neurosurgery
Volume52
Issue number2-4
DOIs
StatePublished - 1989
Externally publishedYes

Keywords

  • Deafferentation pain
  • Human thalamus
  • Microelectrodes
  • Pain
  • Stereotaxis

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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