Reconstruction of hemodynamics and sensitizer distributions during interstitial PDT using spectroscopy with linear light sources

Jarod C. Finlay, Kang-Hsin Wang, Yida Hu, Timothy C. Zhu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Light dosimetry for photodynamic therapy requires a knowledge of the optical absorption spectrum of the tissue being treated Here, we present a theoretical and experimental analysis of the capabilities of a system using interstitial linear light sources ranging in length from 2 to 5 cm to illuminate the tissue interstitially, and isotropic point-like detectors to measure the resulting diffusely transmitted light. The sources and detectors are translated in transparent plastic catheters under the control of a motorized positioning system designed for interstitial measurements in the prostate. The light source is a quartz-tungsten-halogen (QTH), and the spectrally resolved detection is accomplished using a CCD-based grating spectrometer. The data are analyzed using an approximation to the radiative transport equation, assuming homogeneous scattering and heterogeneous absorption spectra Absorption spectra are reconstructed independently for individual source-detector channel pairs. Sequential reconstruction can then be used to create a 3-dimensional reconstruction. The results of simulated data, measurements made in multi-component phantoms, and synthetic data reconstructed from in vivo measurements made with point sources demonstrate the feasibility of this method.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7380
DOIs
StatePublished - 2009
Externally publishedYes
Event12th World Congress of the International Photodynamic Association - Photodynamic Therapy: Back to the Future - Seattle, WA, United States
Duration: Jun 11 2009Jun 15 2009

Other

Other12th World Congress of the International Photodynamic Association - Photodynamic Therapy: Back to the Future
CountryUnited States
CitySeattle, WA
Period6/11/096/15/09

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Keywords

  • dosimetry
  • optical properties
  • Photodynamic therapy

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Finlay, J. C., Wang, K-H., Hu, Y., & Zhu, T. C. (2009). Reconstruction of hemodynamics and sensitizer distributions during interstitial PDT using spectroscopy with linear light sources. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 7380). [738044] https://doi.org/10.1117/12.822964