RECONSTITUTION OF B AND T LYMPHOCYTE FUNCTION IN SEVERE COMBINED IMMUNODEFICIENCY DISEASE AFTER TRANSPLANTATION WITH THYMIC EPITHELIUM

Richard Hong; Mathuram Santosham; Hermann Schulte-Wissermann; Sheldon Horowitz; Susan H. Hsu; Jerry A. Winkelstein

doi:10.1016/S0140-6736(76)92031-6

RECONSTITUTION OF B AND T LYMPHOCYTE FUNCTION IN SEVERE COMBINED IMMUNODEFICIENCY DISEASE AFTER TRANSPLANTATION WITH THYMIC EPITHELIUM

Richard Hong, Mathuram Santosham, Hermann Schulte-Wissermann, Sheldon Horowitz, Susan H. Hsu, Jerry A. Winkelstein

Research output: Contribution to journal › Article › peer-review

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Abstract

A patient with severe combined immunodeficiency has been given a transplant of thymic epithelium obtained from short-term culture of normal human thymus. 4 wk after transplantation immunoglobulin was detected and the patient now has normal levels of the three main classes. Functional antibodies of four specificities have been detected. An increase in reactivity to allogeneic cells and phytohæmagglutinin has been observed, with an increase in E rosettes; a positive delayed skin test to candida antigen is now present. The patient has shown reversal of wasting and has been free of infection for 7 months since receiving the transplant. It appears that under certain circumstances thymic epithelium reconstitutes both T and B cell functions.

Original language	English (US)
Pages (from-to)	1270-1272
Number of pages	3
Journal	The Lancet
Volume	308
Issue number	7998
DOIs	https://doi.org/10.1016/S0140-6736(76)92031-6
State	Published - Dec 11 1976

ASJC Scopus subject areas

General Medicine

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title = "RECONSTITUTION OF B AND T LYMPHOCYTE FUNCTION IN SEVERE COMBINED IMMUNODEFICIENCY DISEASE AFTER TRANSPLANTATION WITH THYMIC EPITHELIUM",

abstract = "A patient with severe combined immunodeficiency has been given a transplant of thymic epithelium obtained from short-term culture of normal human thymus. 4 wk after transplantation immunoglobulin was detected and the patient now has normal levels of the three main classes. Functional antibodies of four specificities have been detected. An increase in reactivity to allogeneic cells and phytoh{\ae}magglutinin has been observed, with an increase in E rosettes; a positive delayed skin test to candida antigen is now present. The patient has shown reversal of wasting and has been free of infection for 7 months since receiving the transplant. It appears that under certain circumstances thymic epithelium reconstitutes both T and B cell functions.",

author = "Richard Hong and Mathuram Santosham and Hermann Schulte-Wissermann and Sheldon Horowitz and Hsu, {Susan H.} and Winkelstein, {Jerry A.}",

note = "Funding Information: by grants from U.S. Public Health Service (GM-19489, HD-07778, AI-11576). H. S. W. is supported by the Deutsche Forschungsgemein- schaft. J. A. W. is an investigator of the Howard Hughes Medical In- stitute. The thymosin was a generous gift from Dr Allan Goldstein, Galveston, Texas. This is paper number 110 from the I.R.C.",

year = "1976",

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day = "11",

doi = "10.1016/S0140-6736(76)92031-6",

language = "English (US)",

volume = "308",

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AU - Hong, Richard

AU - Santosham, Mathuram

AU - Schulte-Wissermann, Hermann

AU - Horowitz, Sheldon

AU - Hsu, Susan H.

AU - Winkelstein, Jerry A.

N1 - Funding Information: by grants from U.S. Public Health Service (GM-19489, HD-07778, AI-11576). H. S. W. is supported by the Deutsche Forschungsgemein- schaft. J. A. W. is an investigator of the Howard Hughes Medical In- stitute. The thymosin was a generous gift from Dr Allan Goldstein, Galveston, Texas. This is paper number 110 from the I.R.C.

PY - 1976/12/11

Y1 - 1976/12/11

N2 - A patient with severe combined immunodeficiency has been given a transplant of thymic epithelium obtained from short-term culture of normal human thymus. 4 wk after transplantation immunoglobulin was detected and the patient now has normal levels of the three main classes. Functional antibodies of four specificities have been detected. An increase in reactivity to allogeneic cells and phytohæmagglutinin has been observed, with an increase in E rosettes; a positive delayed skin test to candida antigen is now present. The patient has shown reversal of wasting and has been free of infection for 7 months since receiving the transplant. It appears that under certain circumstances thymic epithelium reconstitutes both T and B cell functions.

AB - A patient with severe combined immunodeficiency has been given a transplant of thymic epithelium obtained from short-term culture of normal human thymus. 4 wk after transplantation immunoglobulin was detected and the patient now has normal levels of the three main classes. Functional antibodies of four specificities have been detected. An increase in reactivity to allogeneic cells and phytohæmagglutinin has been observed, with an increase in E rosettes; a positive delayed skin test to candida antigen is now present. The patient has shown reversal of wasting and has been free of infection for 7 months since receiving the transplant. It appears that under certain circumstances thymic epithelium reconstitutes both T and B cell functions.

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RECONSTITUTION OF B AND T LYMPHOCYTE FUNCTION IN SEVERE COMBINED IMMUNODEFICIENCY DISEASE AFTER TRANSPLANTATION WITH THYMIC EPITHELIUM

Abstract

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