RECONSTITUTION OF B AND T LYMPHOCYTE FUNCTION IN SEVERE COMBINED IMMUNODEFICIENCY DISEASE AFTER TRANSPLANTATION WITH THYMIC EPITHELIUM

Richard Hong, Mathuram Santosham, Hermann Schulte-Wissermann, Sheldon Horowitz, Susan H. Hsu, Jerry A. Winkelstein

Research output: Contribution to journalArticlepeer-review

Abstract

A patient with severe combined immunodeficiency has been given a transplant of thymic epithelium obtained from short-term culture of normal human thymus. 4 wk after transplantation immunoglobulin was detected and the patient now has normal levels of the three main classes. Functional antibodies of four specificities have been detected. An increase in reactivity to allogeneic cells and phytohæmagglutinin has been observed, with an increase in E rosettes; a positive delayed skin test to candida antigen is now present. The patient has shown reversal of wasting and has been free of infection for 7 months since receiving the transplant. It appears that under certain circumstances thymic epithelium reconstitutes both T and B cell functions.

Original languageEnglish (US)
Pages (from-to)1270-1272
Number of pages3
JournalThe Lancet
Volume308
Issue number7998
DOIs
StatePublished - Dec 11 1976

ASJC Scopus subject areas

  • Medicine(all)

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