Reconstituted olfactory receptors in bilayer lipid membranes

Menekhem Zviman, H. Ti Tien

Research output: Contribution to journalArticlepeer-review

Abstract

Bullfrog olfactory receptors were reconstituted in bilayer lipid membranes (BLMs). Three odorants were presented to the reconstituted system. The three structurally related odorants were diethylsulfide (DES), thiophene (THP) and diethanolsulfide (DOS). The ordorants were presented in pairs. DOS induced a response in the presence of either of the other two odorants. DES and THP did not induce a response in the presence of either of the other two odorants. These observations suggest that there are two substructures, one common to the three odorants and one that is unique to DOS. The results support the notion that olfactory receptors detect certain molecular segments of odorants.

Original languageEnglish (US)
Pages (from-to)127-135
Number of pages9
JournalBioelectrochemistry and Bioenergetics
Volume36
Issue number2
DOIs
StatePublished - Mar 1995

Keywords

  • Bilayer lipid membranes
  • Membrane receptor
  • Olfaction
  • Reconstitution

ASJC Scopus subject areas

  • Biophysics
  • Physical and Theoretical Chemistry
  • Electrochemistry

Fingerprint Dive into the research topics of 'Reconstituted olfactory receptors in bilayer lipid membranes'. Together they form a unique fingerprint.

Cite this