Reconciling the effects of inflammatory cytokines on mesenchymal cell osteogenic differentiation

Sagar Deshpande, Aaron James, Jordan Blough, Alexis Donneys, Stewart C. Wang, Paul S. Cederna, Steven R. Buchman, Benjamin Levi

Research output: Contribution to journalReview article

Abstract

Therapies using mesenchymal stem cells are a popular current avenue for development and utilization, especially in the fields of de novo tissue engineering (Sanchez-Ramos J, Song S, Cardozo-Pelaez F, et al. Adult bone marrow stromal cells differentiate into neural cells in vitro. Exp Neurol 2000;164:247.) or tissue regeneration after physical injury (Kitoh H, Kitakoji T, Tsuchiya H, et al. Transplantation of marrow-derived mesenchymal stem cells and platelet-rich plasma during distraction osteogenesis - a preliminary result of three cases. Bone 2004;35:892; Shumakov VI, Onishchenko NA, Rasulov MF, Krasheninnikov ME, Zaidenov VA. Mesenchymal bone marrow stem cells more effectively stimulate regeneration of deep burn wounds than embryonic fibroblasts. Bull Exp Biol Med 2003;136:192; Bruder SP, Fink DJ, Caplan AI. Mesenchymal stem cells in bone development, bone repair, and skeletal regeneration therapy. J Cell Biochem 1994;56:283.). The osteogenic potential of these cells is of particular interest, given their recent usage for the closure of critical-sized bone defects and other nonhealing bone scenarios such as a nonunion. Recent literature suggests that inflammatory cytokines can significantly impact the osteogenic potential of these cells. A review of relevant, recent literature is presented regarding the impact of the inflammatory cascade on the osteogenic differentiation of these cells and how this varies across species. Finally, we identify areas of conflicting or absent evidence regarding the behavior of mesenchymal stem cells in response to inflammatory cytokines.

Original languageEnglish (US)
Pages (from-to)278-285
Number of pages8
JournalJournal of Surgical Research
Volume185
Issue number1
DOIs
StatePublished - Nov 2013
Externally publishedYes

Fingerprint

Mesenchymal Stromal Cells
Cell Differentiation
Cytokines
Bone and Bones
Regeneration
Distraction Osteogenesis
Platelet-Rich Plasma
Bone Development
Wounds and Injuries
Tissue Engineering
Music
Bone Marrow Cells
Stem Cells
Fibroblasts
Transplantation
Bone Marrow
Therapeutics

Keywords

  • Adipose-derived stromal cell
  • Inflammation
  • Mesenchymal cell

ASJC Scopus subject areas

  • Surgery

Cite this

Reconciling the effects of inflammatory cytokines on mesenchymal cell osteogenic differentiation. / Deshpande, Sagar; James, Aaron; Blough, Jordan; Donneys, Alexis; Wang, Stewart C.; Cederna, Paul S.; Buchman, Steven R.; Levi, Benjamin.

In: Journal of Surgical Research, Vol. 185, No. 1, 11.2013, p. 278-285.

Research output: Contribution to journalReview article

Deshpande, S, James, A, Blough, J, Donneys, A, Wang, SC, Cederna, PS, Buchman, SR & Levi, B 2013, 'Reconciling the effects of inflammatory cytokines on mesenchymal cell osteogenic differentiation', Journal of Surgical Research, vol. 185, no. 1, pp. 278-285. https://doi.org/10.1016/j.jss.2013.06.063
Deshpande, Sagar ; James, Aaron ; Blough, Jordan ; Donneys, Alexis ; Wang, Stewart C. ; Cederna, Paul S. ; Buchman, Steven R. ; Levi, Benjamin. / Reconciling the effects of inflammatory cytokines on mesenchymal cell osteogenic differentiation. In: Journal of Surgical Research. 2013 ; Vol. 185, No. 1. pp. 278-285.
@article{7ecc1e755cbc44e3ad8053815d27b27d,
title = "Reconciling the effects of inflammatory cytokines on mesenchymal cell osteogenic differentiation",
abstract = "Therapies using mesenchymal stem cells are a popular current avenue for development and utilization, especially in the fields of de novo tissue engineering (Sanchez-Ramos J, Song S, Cardozo-Pelaez F, et al. Adult bone marrow stromal cells differentiate into neural cells in vitro. Exp Neurol 2000;164:247.) or tissue regeneration after physical injury (Kitoh H, Kitakoji T, Tsuchiya H, et al. Transplantation of marrow-derived mesenchymal stem cells and platelet-rich plasma during distraction osteogenesis - a preliminary result of three cases. Bone 2004;35:892; Shumakov VI, Onishchenko NA, Rasulov MF, Krasheninnikov ME, Zaidenov VA. Mesenchymal bone marrow stem cells more effectively stimulate regeneration of deep burn wounds than embryonic fibroblasts. Bull Exp Biol Med 2003;136:192; Bruder SP, Fink DJ, Caplan AI. Mesenchymal stem cells in bone development, bone repair, and skeletal regeneration therapy. J Cell Biochem 1994;56:283.). The osteogenic potential of these cells is of particular interest, given their recent usage for the closure of critical-sized bone defects and other nonhealing bone scenarios such as a nonunion. Recent literature suggests that inflammatory cytokines can significantly impact the osteogenic potential of these cells. A review of relevant, recent literature is presented regarding the impact of the inflammatory cascade on the osteogenic differentiation of these cells and how this varies across species. Finally, we identify areas of conflicting or absent evidence regarding the behavior of mesenchymal stem cells in response to inflammatory cytokines.",
keywords = "Adipose-derived stromal cell, Inflammation, Mesenchymal cell",
author = "Sagar Deshpande and Aaron James and Jordan Blough and Alexis Donneys and Wang, {Stewart C.} and Cederna, {Paul S.} and Buchman, {Steven R.} and Benjamin Levi",
year = "2013",
month = "11",
doi = "10.1016/j.jss.2013.06.063",
language = "English (US)",
volume = "185",
pages = "278--285",
journal = "Journal of Surgical Research",
issn = "0022-4804",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - Reconciling the effects of inflammatory cytokines on mesenchymal cell osteogenic differentiation

AU - Deshpande, Sagar

AU - James, Aaron

AU - Blough, Jordan

AU - Donneys, Alexis

AU - Wang, Stewart C.

AU - Cederna, Paul S.

AU - Buchman, Steven R.

AU - Levi, Benjamin

PY - 2013/11

Y1 - 2013/11

N2 - Therapies using mesenchymal stem cells are a popular current avenue for development and utilization, especially in the fields of de novo tissue engineering (Sanchez-Ramos J, Song S, Cardozo-Pelaez F, et al. Adult bone marrow stromal cells differentiate into neural cells in vitro. Exp Neurol 2000;164:247.) or tissue regeneration after physical injury (Kitoh H, Kitakoji T, Tsuchiya H, et al. Transplantation of marrow-derived mesenchymal stem cells and platelet-rich plasma during distraction osteogenesis - a preliminary result of three cases. Bone 2004;35:892; Shumakov VI, Onishchenko NA, Rasulov MF, Krasheninnikov ME, Zaidenov VA. Mesenchymal bone marrow stem cells more effectively stimulate regeneration of deep burn wounds than embryonic fibroblasts. Bull Exp Biol Med 2003;136:192; Bruder SP, Fink DJ, Caplan AI. Mesenchymal stem cells in bone development, bone repair, and skeletal regeneration therapy. J Cell Biochem 1994;56:283.). The osteogenic potential of these cells is of particular interest, given their recent usage for the closure of critical-sized bone defects and other nonhealing bone scenarios such as a nonunion. Recent literature suggests that inflammatory cytokines can significantly impact the osteogenic potential of these cells. A review of relevant, recent literature is presented regarding the impact of the inflammatory cascade on the osteogenic differentiation of these cells and how this varies across species. Finally, we identify areas of conflicting or absent evidence regarding the behavior of mesenchymal stem cells in response to inflammatory cytokines.

AB - Therapies using mesenchymal stem cells are a popular current avenue for development and utilization, especially in the fields of de novo tissue engineering (Sanchez-Ramos J, Song S, Cardozo-Pelaez F, et al. Adult bone marrow stromal cells differentiate into neural cells in vitro. Exp Neurol 2000;164:247.) or tissue regeneration after physical injury (Kitoh H, Kitakoji T, Tsuchiya H, et al. Transplantation of marrow-derived mesenchymal stem cells and platelet-rich plasma during distraction osteogenesis - a preliminary result of three cases. Bone 2004;35:892; Shumakov VI, Onishchenko NA, Rasulov MF, Krasheninnikov ME, Zaidenov VA. Mesenchymal bone marrow stem cells more effectively stimulate regeneration of deep burn wounds than embryonic fibroblasts. Bull Exp Biol Med 2003;136:192; Bruder SP, Fink DJ, Caplan AI. Mesenchymal stem cells in bone development, bone repair, and skeletal regeneration therapy. J Cell Biochem 1994;56:283.). The osteogenic potential of these cells is of particular interest, given their recent usage for the closure of critical-sized bone defects and other nonhealing bone scenarios such as a nonunion. Recent literature suggests that inflammatory cytokines can significantly impact the osteogenic potential of these cells. A review of relevant, recent literature is presented regarding the impact of the inflammatory cascade on the osteogenic differentiation of these cells and how this varies across species. Finally, we identify areas of conflicting or absent evidence regarding the behavior of mesenchymal stem cells in response to inflammatory cytokines.

KW - Adipose-derived stromal cell

KW - Inflammation

KW - Mesenchymal cell

UR - http://www.scopus.com/inward/record.url?scp=84886730147&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84886730147&partnerID=8YFLogxK

U2 - 10.1016/j.jss.2013.06.063

DO - 10.1016/j.jss.2013.06.063

M3 - Review article

C2 - 23972621

AN - SCOPUS:84886730147

VL - 185

SP - 278

EP - 285

JO - Journal of Surgical Research

JF - Journal of Surgical Research

SN - 0022-4804

IS - 1

ER -