Recommendations for standardized pathological characterization of residual disease for neoadjuvant clinical trials of breast cancer by the BIG-NABCG collaboration

Veerle Bossuyt, E. Provenzano, W. F. Symmans, J. C. Boughey, C. Coles, G. Curigliano, J. M. Dixon, L. J. Esserman, G. Fastner, T. Kuehn, F. Peintinger, G. Von Minckwitz, J. White, W. Yang, S. Badve, C. Denkert, G. MacGrogan, F. Penault-Llorca, G. Viale, D. Cameron & 37 others Nancy E. Davidson, Martine Piccart, Larry Norton, Helena Earl, Emilio Alba, Ana Lluch, Joan Albanell, Keith Amos, Véronique Becette, Wojciech Biernat, Hervé Bonnefoi, Aman Buzdar, Paul Cane, Sarah Pinder, Lesley Carson, Diana Dickson-Witmer, Gyungyub Gong, Jimmy Green, Chih Yi Hsu, Ling Ming Tseng, Judith Kroep, A. Marilyn Leitch, Venetia Sarode, Eleftherios Mamounas, Paul Kelly Marcom, Paolo Nuciforo, Soonmyung Paik, Vicente Peg, David Peston, Jean Yves Pierga, Miguel Quintela-Fandino, Roberto Salgado, William Sikov, Jeremy Thomas, Gary Unzeitig, Jelle Wesseling, Marc Wilt

Research output: Contribution to journalArticle

Abstract

Neoadjuvant systemic therapy (NAST) provides the unique opportunity to assess response to treatment after months rather than years of follow-up. However, significant variability exists in methods of pathologic assessment of response to NAST, and thus its interpretation for subsequent clinical decisions. Our international multidisciplinary working group was convened by the Breast International Group-North American Breast Cancer Group (BIG-NABCG) collaboration and tasked to recommend practical methods for standardized evaluation of the post-NAST surgical breast cancer specimen for clinical trials that promote accurate and reliable designation of pathologic complete response (pCR) and meaningful characterization of residual disease. Recommendations include multidisciplinary communication; clinical marking of the tumor site (clips); and radiologic, photographic, or pictorial imaging of the sliced specimen, to map the tissue sections and reconcile macroscopic and microscopic findings. The information required to define pCR (ypT0/is ypN0 or ypT0 yp N0), residual ypT and ypN stage using the current AJCC/UICC system, and the Residual Cancer Burden system were recommended for quantification of residual disease in clinical trials.

Original languageEnglish (US)
Pages (from-to)1280-1291
Number of pages12
JournalAnnals of Oncology
Volume26
Issue number7
DOIs
StatePublished - Jul 1 2015
Externally publishedYes

Fingerprint

Neoadjuvant Therapy
Clinical Trials
Breast Neoplasms
Interdisciplinary Communication
Residual Neoplasm
Surgical Instruments
Breast
Neoplasms
Therapeutics

Keywords

  • Breast cancer
  • Neoadjuvant systemic therapy
  • Pathologic assessment
  • Pathologic complete response
  • Residual disease
  • Response evaluation

ASJC Scopus subject areas

  • Oncology
  • Hematology

Cite this

Recommendations for standardized pathological characterization of residual disease for neoadjuvant clinical trials of breast cancer by the BIG-NABCG collaboration. / Bossuyt, Veerle; Provenzano, E.; Symmans, W. F.; Boughey, J. C.; Coles, C.; Curigliano, G.; Dixon, J. M.; Esserman, L. J.; Fastner, G.; Kuehn, T.; Peintinger, F.; Von Minckwitz, G.; White, J.; Yang, W.; Badve, S.; Denkert, C.; MacGrogan, G.; Penault-Llorca, F.; Viale, G.; Cameron, D.; Davidson, Nancy E.; Piccart, Martine; Norton, Larry; Earl, Helena; Alba, Emilio; Lluch, Ana; Albanell, Joan; Amos, Keith; Becette, Véronique; Biernat, Wojciech; Bonnefoi, Hervé; Buzdar, Aman; Cane, Paul; Pinder, Sarah; Carson, Lesley; Dickson-Witmer, Diana; Gong, Gyungyub; Green, Jimmy; Hsu, Chih Yi; Tseng, Ling Ming; Kroep, Judith; Marilyn Leitch, A.; Sarode, Venetia; Mamounas, Eleftherios; Marcom, Paul Kelly; Nuciforo, Paolo; Paik, Soonmyung; Peg, Vicente; Peston, David; Pierga, Jean Yves; Quintela-Fandino, Miguel; Salgado, Roberto; Sikov, William; Thomas, Jeremy; Unzeitig, Gary; Wesseling, Jelle; Wilt, Marc.

In: Annals of Oncology, Vol. 26, No. 7, 01.07.2015, p. 1280-1291.

Research output: Contribution to journalArticle

Bossuyt, V, Provenzano, E, Symmans, WF, Boughey, JC, Coles, C, Curigliano, G, Dixon, JM, Esserman, LJ, Fastner, G, Kuehn, T, Peintinger, F, Von Minckwitz, G, White, J, Yang, W, Badve, S, Denkert, C, MacGrogan, G, Penault-Llorca, F, Viale, G, Cameron, D, Davidson, NE, Piccart, M, Norton, L, Earl, H, Alba, E, Lluch, A, Albanell, J, Amos, K, Becette, V, Biernat, W, Bonnefoi, H, Buzdar, A, Cane, P, Pinder, S, Carson, L, Dickson-Witmer, D, Gong, G, Green, J, Hsu, CY, Tseng, LM, Kroep, J, Marilyn Leitch, A, Sarode, V, Mamounas, E, Marcom, PK, Nuciforo, P, Paik, S, Peg, V, Peston, D, Pierga, JY, Quintela-Fandino, M, Salgado, R, Sikov, W, Thomas, J, Unzeitig, G, Wesseling, J & Wilt, M 2015, 'Recommendations for standardized pathological characterization of residual disease for neoadjuvant clinical trials of breast cancer by the BIG-NABCG collaboration', Annals of Oncology, vol. 26, no. 7, pp. 1280-1291. https://doi.org/10.1093/annonc/mdv161
Bossuyt, Veerle ; Provenzano, E. ; Symmans, W. F. ; Boughey, J. C. ; Coles, C. ; Curigliano, G. ; Dixon, J. M. ; Esserman, L. J. ; Fastner, G. ; Kuehn, T. ; Peintinger, F. ; Von Minckwitz, G. ; White, J. ; Yang, W. ; Badve, S. ; Denkert, C. ; MacGrogan, G. ; Penault-Llorca, F. ; Viale, G. ; Cameron, D. ; Davidson, Nancy E. ; Piccart, Martine ; Norton, Larry ; Earl, Helena ; Alba, Emilio ; Lluch, Ana ; Albanell, Joan ; Amos, Keith ; Becette, Véronique ; Biernat, Wojciech ; Bonnefoi, Hervé ; Buzdar, Aman ; Cane, Paul ; Pinder, Sarah ; Carson, Lesley ; Dickson-Witmer, Diana ; Gong, Gyungyub ; Green, Jimmy ; Hsu, Chih Yi ; Tseng, Ling Ming ; Kroep, Judith ; Marilyn Leitch, A. ; Sarode, Venetia ; Mamounas, Eleftherios ; Marcom, Paul Kelly ; Nuciforo, Paolo ; Paik, Soonmyung ; Peg, Vicente ; Peston, David ; Pierga, Jean Yves ; Quintela-Fandino, Miguel ; Salgado, Roberto ; Sikov, William ; Thomas, Jeremy ; Unzeitig, Gary ; Wesseling, Jelle ; Wilt, Marc. / Recommendations for standardized pathological characterization of residual disease for neoadjuvant clinical trials of breast cancer by the BIG-NABCG collaboration. In: Annals of Oncology. 2015 ; Vol. 26, No. 7. pp. 1280-1291.
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AU - Provenzano, E.

AU - Symmans, W. F.

AU - Boughey, J. C.

AU - Coles, C.

AU - Curigliano, G.

AU - Dixon, J. M.

AU - Esserman, L. J.

AU - Fastner, G.

AU - Kuehn, T.

AU - Peintinger, F.

AU - Von Minckwitz, G.

AU - White, J.

AU - Yang, W.

AU - Badve, S.

AU - Denkert, C.

AU - MacGrogan, G.

AU - Penault-Llorca, F.

AU - Viale, G.

AU - Cameron, D.

AU - Davidson, Nancy E.

AU - Piccart, Martine

AU - Norton, Larry

AU - Earl, Helena

AU - Alba, Emilio

AU - Lluch, Ana

AU - Albanell, Joan

AU - Amos, Keith

AU - Becette, Véronique

AU - Biernat, Wojciech

AU - Bonnefoi, Hervé

AU - Buzdar, Aman

AU - Cane, Paul

AU - Pinder, Sarah

AU - Carson, Lesley

AU - Dickson-Witmer, Diana

AU - Gong, Gyungyub

AU - Green, Jimmy

AU - Hsu, Chih Yi

AU - Tseng, Ling Ming

AU - Kroep, Judith

AU - Marilyn Leitch, A.

AU - Sarode, Venetia

AU - Mamounas, Eleftherios

AU - Marcom, Paul Kelly

AU - Nuciforo, Paolo

AU - Paik, Soonmyung

AU - Peg, Vicente

AU - Peston, David

AU - Pierga, Jean Yves

AU - Quintela-Fandino, Miguel

AU - Salgado, Roberto

AU - Sikov, William

AU - Thomas, Jeremy

AU - Unzeitig, Gary

AU - Wesseling, Jelle

AU - Wilt, Marc

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KW - Neoadjuvant systemic therapy

KW - Pathologic assessment

KW - Pathologic complete response

KW - Residual disease

KW - Response evaluation

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