Recommendations for minimum information for publication of experimental pathology data: MINPEPA guidelines

Cheryl L. Scudamore, Elizabeth J. Soilleux, Natasha A. Karp, Ken Smith, Richard Poulsom, C. Simon Herrington, Michael J. Day, Cory Brayton, Brad Bolon, Bruce Whitelaw, Eric S. White, Jeffrey I. Everitt, Mark J. Arends

Research output: Contribution to journalArticle

Abstract

Animal models are essential research tools in modern biomedical research, but there are concerns about their lack of reproducibility and the failure of animal data to translate into advances in human medical therapy. A major factor in improving experimental reproducibility is thorough communication of research methodologies. The recently published ARRIVE guidelines outline basic information that should be provided when reporting animal studies. This paper builds on ARRIVE by providing the minimum information needed in reports to allow proper assessment of pathology data gathered from animal tissues. This guidance covers aspects of experimental design, technical procedures, data gathering, analysis, and presentation that are potential sources of variation when creating morphological, immunohistochemical (IHC) or in situ hybridization (ISH) datasets. This reporting framework will maximize the likelihood that pathology data derived from animal experiments can be reproduced by ensuring that sufficient information is available to allow for replication of the methods and facilitate inter-study comparison by identifying potential interpretative confounders.

Original languageEnglish (US)
Pages (from-to)359-367
Number of pages9
JournalJournal of Pathology
Volume238
Issue number2
DOIs
StatePublished - Jan 1 2016

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Keywords

  • ARRIVE
  • Experimental pathology
  • Guidelines
  • Review
  • Translational research

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Scudamore, C. L., Soilleux, E. J., Karp, N. A., Smith, K., Poulsom, R., Simon Herrington, C., ... Arends, M. J. (2016). Recommendations for minimum information for publication of experimental pathology data: MINPEPA guidelines. Journal of Pathology, 238(2), 359-367. https://doi.org/10.1002/path.4642

Recommendations for minimum information for publication of experimental pathology data : MINPEPA guidelines. / Scudamore, Cheryl L.; Soilleux, Elizabeth J.; Karp, Natasha A.; Smith, Ken; Poulsom, Richard; Simon Herrington, C.; Day, Michael J.; Brayton, Cory; Bolon, Brad; Whitelaw, Bruce; White, Eric S.; Everitt, Jeffrey I.; Arends, Mark J.

In: Journal of Pathology, Vol. 238, No. 2, 01.01.2016, p. 359-367.

Research output: Contribution to journalArticle

Scudamore, CL, Soilleux, EJ, Karp, NA, Smith, K, Poulsom, R, Simon Herrington, C, Day, MJ, Brayton, C, Bolon, B, Whitelaw, B, White, ES, Everitt, JI & Arends, MJ 2016, 'Recommendations for minimum information for publication of experimental pathology data: MINPEPA guidelines', Journal of Pathology, vol. 238, no. 2, pp. 359-367. https://doi.org/10.1002/path.4642
Scudamore CL, Soilleux EJ, Karp NA, Smith K, Poulsom R, Simon Herrington C et al. Recommendations for minimum information for publication of experimental pathology data: MINPEPA guidelines. Journal of Pathology. 2016 Jan 1;238(2):359-367. https://doi.org/10.1002/path.4642
Scudamore, Cheryl L. ; Soilleux, Elizabeth J. ; Karp, Natasha A. ; Smith, Ken ; Poulsom, Richard ; Simon Herrington, C. ; Day, Michael J. ; Brayton, Cory ; Bolon, Brad ; Whitelaw, Bruce ; White, Eric S. ; Everitt, Jeffrey I. ; Arends, Mark J. / Recommendations for minimum information for publication of experimental pathology data : MINPEPA guidelines. In: Journal of Pathology. 2016 ; Vol. 238, No. 2. pp. 359-367.
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