Recombination in telomere-length maintenance

Alyson Kass-Eisler, Carol W. Greider

Research output: Contribution to journalReview articlepeer-review

Abstract

Although telomerase is the major mechanism for telomere elongation in most cells, telomerase-independent mechanisms of telomere maintenance can allow cell survival. Yeast cells that lack telomerase maintain telomere length through a form of recombination known as gene conversion. Understanding the role that telomeric recombination might play in mammalian cells has important implications for cancer therapeutics. Copyright (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)200-204
Number of pages5
JournalTrends in biochemical sciences
Volume25
Issue number4
DOIs
StatePublished - Apr 1 2000

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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