Recombination in telomere-length maintenance

Alyson Kass-Eisler; Carol W. Greider

doi:10.1016/S0968-0004(00)01557-7

Recombination in telomere-length maintenance

Alyson Kass-Eisler, Carol W. Greider

School of Medicine

Research output: Contribution to journal › Review article › peer-review

81 Scopus citations

Abstract

Although telomerase is the major mechanism for telomere elongation in most cells, telomerase-independent mechanisms of telomere maintenance can allow cell survival. Yeast cells that lack telomerase maintain telomere length through a form of recombination known as gene conversion. Understanding the role that telomeric recombination might play in mammalian cells has important implications for cancer therapeutics. Copyright (C) 2000 Elsevier Science Ltd.

Original language	English (US)
Pages (from-to)	200-204
Number of pages	5
Journal	Trends in biochemical sciences
Volume	25
Issue number	4
DOIs	https://doi.org/10.1016/S0968-0004(00)01557-7
State	Published - Apr 1 2000

ASJC Scopus subject areas

Biochemistry
Molecular Biology

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10.1016/S0968-0004(00)01557-7

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@article{2662c1bf7a704434b777be7508cc5079,

title = "Recombination in telomere-length maintenance",

abstract = "Although telomerase is the major mechanism for telomere elongation in most cells, telomerase-independent mechanisms of telomere maintenance can allow cell survival. Yeast cells that lack telomerase maintain telomere length through a form of recombination known as gene conversion. Understanding the role that telomeric recombination might play in mammalian cells has important implications for cancer therapeutics. Copyright (C) 2000 Elsevier Science Ltd.",

author = "Alyson Kass-Eisler and Greider, {Carol W.}",

note = "Funding Information: We would like to thank Siyuan Le, Mike McEachern and James Haber for critical reading of the manuscript. We would also like to thank Mike McEachern and Virginia Zakian for sharing data with us before publication. A.K-E. has been supported by an American Cancer Society Postdoctoral Fellowship (PF-4341). Work on recombination in the lab of C.W.G. is supported by the Ellison Foundation and the NIH (GM43080).",

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T1 - Recombination in telomere-length maintenance

AU - Kass-Eisler, Alyson

AU - Greider, Carol W.

N1 - Funding Information: We would like to thank Siyuan Le, Mike McEachern and James Haber for critical reading of the manuscript. We would also like to thank Mike McEachern and Virginia Zakian for sharing data with us before publication. A.K-E. has been supported by an American Cancer Society Postdoctoral Fellowship (PF-4341). Work on recombination in the lab of C.W.G. is supported by the Ellison Foundation and the NIH (GM43080).

PY - 2000/4/1

Y1 - 2000/4/1

N2 - Although telomerase is the major mechanism for telomere elongation in most cells, telomerase-independent mechanisms of telomere maintenance can allow cell survival. Yeast cells that lack telomerase maintain telomere length through a form of recombination known as gene conversion. Understanding the role that telomeric recombination might play in mammalian cells has important implications for cancer therapeutics. Copyright (C) 2000 Elsevier Science Ltd.

AB - Although telomerase is the major mechanism for telomere elongation in most cells, telomerase-independent mechanisms of telomere maintenance can allow cell survival. Yeast cells that lack telomerase maintain telomere length through a form of recombination known as gene conversion. Understanding the role that telomeric recombination might play in mammalian cells has important implications for cancer therapeutics. Copyright (C) 2000 Elsevier Science Ltd.

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U2 - 10.1016/S0968-0004(00)01557-7

DO - 10.1016/S0968-0004(00)01557-7

M3 - Review article

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AN - SCOPUS:0034176261

SN - 0968-0004

VL - 25

SP - 200

EP - 204

JO - Trends in biochemical sciences

JF - Trends in biochemical sciences

IS - 4

ER -

Recombination in telomere-length maintenance

Abstract

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