Recombination in HIV: An Important Viral Evolutionary Strategy

Donald S. Burke

Research output: Contribution to journalArticle

Abstract

Human immunodeficiency virus (HIV) is a diploid virus: each virion carries two complete RNA genomic strands. Homologous recombination can occur when a cell is coinfected with two different but related strains. Naturally occurring recombinant HIV strains have been found in infected patients in regions of the world where multiple genotypic variants cocirculate. One recombinant HIV strain has spread rapidly to millions of persons in Southeast Asia. Recombination is a mechanism whereby high level and multidrug-resistant strains may be generated in individual treated patients. Recombination also poses theoretical problems for the development of a safe HIV vaccine. Certain features of HIV replication, such as syncytium formation and transactivation, may be best understood as components of a sexual reproductive cycle. Recombination may be an important HIV evolutionary strategy.

Original languageEnglish (US)
Pages (from-to)253-259
Number of pages7
JournalEmerging Infectious Diseases
Volume3
Issue number3
StatePublished - Jul 1997
Externally publishedYes

Fingerprint

Genetic Recombination
HIV
Southeastern Asia
Homologous Recombination
Giant Cells
Virus Replication
Diploidy
Virion
Transcriptional Activation
Vaccines
RNA
Viruses

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Recombination in HIV : An Important Viral Evolutionary Strategy. / Burke, Donald S.

In: Emerging Infectious Diseases, Vol. 3, No. 3, 07.1997, p. 253-259.

Research output: Contribution to journalArticle

Burke, Donald S. / Recombination in HIV : An Important Viral Evolutionary Strategy. In: Emerging Infectious Diseases. 1997 ; Vol. 3, No. 3. pp. 253-259.
@article{30a508a3bd344ddcaea3cc6be0485602,
title = "Recombination in HIV: An Important Viral Evolutionary Strategy",
abstract = "Human immunodeficiency virus (HIV) is a diploid virus: each virion carries two complete RNA genomic strands. Homologous recombination can occur when a cell is coinfected with two different but related strains. Naturally occurring recombinant HIV strains have been found in infected patients in regions of the world where multiple genotypic variants cocirculate. One recombinant HIV strain has spread rapidly to millions of persons in Southeast Asia. Recombination is a mechanism whereby high level and multidrug-resistant strains may be generated in individual treated patients. Recombination also poses theoretical problems for the development of a safe HIV vaccine. Certain features of HIV replication, such as syncytium formation and transactivation, may be best understood as components of a sexual reproductive cycle. Recombination may be an important HIV evolutionary strategy.",
author = "Burke, {Donald S.}",
year = "1997",
month = "7",
language = "English (US)",
volume = "3",
pages = "253--259",
journal = "Emerging Infectious Diseases",
issn = "1080-6040",
publisher = "Centers for Disease Control and Prevention (CDC)",
number = "3",

}

TY - JOUR

T1 - Recombination in HIV

T2 - An Important Viral Evolutionary Strategy

AU - Burke, Donald S.

PY - 1997/7

Y1 - 1997/7

N2 - Human immunodeficiency virus (HIV) is a diploid virus: each virion carries two complete RNA genomic strands. Homologous recombination can occur when a cell is coinfected with two different but related strains. Naturally occurring recombinant HIV strains have been found in infected patients in regions of the world where multiple genotypic variants cocirculate. One recombinant HIV strain has spread rapidly to millions of persons in Southeast Asia. Recombination is a mechanism whereby high level and multidrug-resistant strains may be generated in individual treated patients. Recombination also poses theoretical problems for the development of a safe HIV vaccine. Certain features of HIV replication, such as syncytium formation and transactivation, may be best understood as components of a sexual reproductive cycle. Recombination may be an important HIV evolutionary strategy.

AB - Human immunodeficiency virus (HIV) is a diploid virus: each virion carries two complete RNA genomic strands. Homologous recombination can occur when a cell is coinfected with two different but related strains. Naturally occurring recombinant HIV strains have been found in infected patients in regions of the world where multiple genotypic variants cocirculate. One recombinant HIV strain has spread rapidly to millions of persons in Southeast Asia. Recombination is a mechanism whereby high level and multidrug-resistant strains may be generated in individual treated patients. Recombination also poses theoretical problems for the development of a safe HIV vaccine. Certain features of HIV replication, such as syncytium formation and transactivation, may be best understood as components of a sexual reproductive cycle. Recombination may be an important HIV evolutionary strategy.

UR - http://www.scopus.com/inward/record.url?scp=0031179130&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031179130&partnerID=8YFLogxK

M3 - Article

C2 - 9284369

AN - SCOPUS:0031179130

VL - 3

SP - 253

EP - 259

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

SN - 1080-6040

IS - 3

ER -