Recombinant sindbis viruses expressing a cytotoxic T-lymphocyte epitope of a malaria parasite or of influenza virus elicit protection against the corresponding pathogen in mice

M. Tsuji, C. C. Bergmann, Y. Takita-Sonoda, K. I. Murata, E. G. Rodrigues, R. S. Nussenzweig, F. Zavala

Research output: Contribution to journalArticlepeer-review

Abstract

Subcutaneous administration in mice of recombinant Sindbis viruses expressing a class I major histocompatibility complex-restricted 9-mer epitope of the Plasmodium yoelii circumsporozoite protein or the nucleoprotein of influenza virus induces a large epitope-specific CD8+ T- cell response. This immunization also elicits a high degree of protection against infection with malaria or influenza A virus.

Original languageEnglish (US)
Pages (from-to)6907-6910
Number of pages4
JournalJournal of virology
Volume72
Issue number8
DOIs
StatePublished - 1998

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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