Recombinant sindbis viruses expressing a cytotoxic T-lymphocyte epitope of a malaria parasite or of influenza virus elicit protection against the corresponding pathogen in mice

M. Tsuji, C. C. Bergmann, Y. Takita-Sonoda, K. I. Murata, E. G. Rodrigues, R. S. Nussenzweig, Fidel P Zavala

Research output: Contribution to journalArticle

Abstract

Subcutaneous administration in mice of recombinant Sindbis viruses expressing a class I major histocompatibility complex-restricted 9-mer epitope of the Plasmodium yoelii circumsporozoite protein or the nucleoprotein of influenza virus induces a large epitope-specific CD8+ T- cell response. This immunization also elicits a high degree of protection against infection with malaria or influenza A virus.

Original languageEnglish (US)
Pages (from-to)6907-6910
Number of pages4
JournalJournal of Virology
Volume72
Issue number8
StatePublished - 1998
Externally publishedYes

Fingerprint

Sindbis virus
Sindbis Virus
cytotoxic T-lymphocytes
T-Lymphocyte Epitopes
Cytotoxic T-Lymphocytes
Orthomyxoviridae
malaria
epitopes
Malaria
Epitopes
Parasites
Plasmodium yoelii
parasites
nucleoproteins
Nucleoproteins
pathogens
Influenza A virus
mice
subcutaneous injection
major histocompatibility complex

ASJC Scopus subject areas

  • Immunology

Cite this

Recombinant sindbis viruses expressing a cytotoxic T-lymphocyte epitope of a malaria parasite or of influenza virus elicit protection against the corresponding pathogen in mice. / Tsuji, M.; Bergmann, C. C.; Takita-Sonoda, Y.; Murata, K. I.; Rodrigues, E. G.; Nussenzweig, R. S.; Zavala, Fidel P.

In: Journal of Virology, Vol. 72, No. 8, 1998, p. 6907-6910.

Research output: Contribution to journalArticle

Tsuji, M. ; Bergmann, C. C. ; Takita-Sonoda, Y. ; Murata, K. I. ; Rodrigues, E. G. ; Nussenzweig, R. S. ; Zavala, Fidel P. / Recombinant sindbis viruses expressing a cytotoxic T-lymphocyte epitope of a malaria parasite or of influenza virus elicit protection against the corresponding pathogen in mice. In: Journal of Virology. 1998 ; Vol. 72, No. 8. pp. 6907-6910.
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