Recombinant interleukin-7 induces proliferation of naive macaque CD4 + and CD8+ T cells in vivo

Marcin Moniuszko, Terry Fry, Wen Po Tsai, Michel Morre, Brigitte Assouline, Pierre Cortez, Mark G. Lewis, Scott Cairns, Crystal Mackall, Genoveffa Franchini

Research output: Contribution to journalArticle

Abstract

Interleukin-7 (IL-7) regulates T-cell homeostasis, and its availability is augmented in lymphopenic hosts. Naive CD8+ T cells transferred to lymphopenic mice acquire a memory-like phenotype, raising the possibility that IL-7 is the biological mediator of this effect. Here, we provide direct evidence that IL-7 induces the acquisition of memory-cell markers not only in CD8 + T cells but also in CD4+ T-cell subsets in immune-competent Indian rhesus macaques. The increase of these memory-like populations was dependent on the dose of the cytokine, and these cells were found in the blood as well as secondary lymphoid organs. Memory-like CD4 + and CD8+ T cells acquired the ability to secrete tumor necrosis factor alpha and, to a lesser extent, gamma interferon following stimulation with a cognate antigen. The phenotypic change observed in naive T cells was promptly reversed after discontinuation of IL-7. Importantly, IL-7 induced cycling of both CD4+ and CD8+ central memory and effector memory T cells, demonstrating its contribution to the maintenance of the entire T-cell pool. Thus, IL-7 may be of benefit in the treatment of iatrogenic or virus-induced T-cell depletion.

Original languageEnglish (US)
Pages (from-to)9740-9749
Number of pages10
JournalJournal of Virology
Volume78
Issue number18
DOIs
StatePublished - Sep 2004
Externally publishedYes

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interleukin-7
Interleukin-7
Macaca
T-lymphocytes
T-Lymphocytes
Aptitude
T-Lymphocyte Subsets
Macaca mulatta
Interferon-gamma
interferon-gamma
tumor necrosis factor-alpha
Homeostasis
Tumor Necrosis Factor-alpha
homeostasis
Maintenance
cytokines
Cytokines
Viruses
Phenotype
Antigens

ASJC Scopus subject areas

  • Immunology

Cite this

Moniuszko, M., Fry, T., Tsai, W. P., Morre, M., Assouline, B., Cortez, P., ... Franchini, G. (2004). Recombinant interleukin-7 induces proliferation of naive macaque CD4 + and CD8+ T cells in vivo. Journal of Virology, 78(18), 9740-9749. https://doi.org/10.1128/JVI.78.18.9740-9749.2004

Recombinant interleukin-7 induces proliferation of naive macaque CD4 + and CD8+ T cells in vivo. / Moniuszko, Marcin; Fry, Terry; Tsai, Wen Po; Morre, Michel; Assouline, Brigitte; Cortez, Pierre; Lewis, Mark G.; Cairns, Scott; Mackall, Crystal; Franchini, Genoveffa.

In: Journal of Virology, Vol. 78, No. 18, 09.2004, p. 9740-9749.

Research output: Contribution to journalArticle

Moniuszko, M, Fry, T, Tsai, WP, Morre, M, Assouline, B, Cortez, P, Lewis, MG, Cairns, S, Mackall, C & Franchini, G 2004, 'Recombinant interleukin-7 induces proliferation of naive macaque CD4 + and CD8+ T cells in vivo', Journal of Virology, vol. 78, no. 18, pp. 9740-9749. https://doi.org/10.1128/JVI.78.18.9740-9749.2004
Moniuszko, Marcin ; Fry, Terry ; Tsai, Wen Po ; Morre, Michel ; Assouline, Brigitte ; Cortez, Pierre ; Lewis, Mark G. ; Cairns, Scott ; Mackall, Crystal ; Franchini, Genoveffa. / Recombinant interleukin-7 induces proliferation of naive macaque CD4 + and CD8+ T cells in vivo. In: Journal of Virology. 2004 ; Vol. 78, No. 18. pp. 9740-9749.
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