Recombinant human myelin P2 protein: Expression and implications

Pallavi C. Ishwad, Benedetta Ripepi, Weili Weng, Shari Olinsky, Vinodh Narayanan

Research output: Contribution to journalArticlepeer-review

Abstract

Autoimmune reactions to human myelin P2 protein have been implicated in demyelinating disorders of the peripheral and central nervous system. The myelin P2 protein belongs to a family of fatty acid binding proteins, and may play an important metabolic role during myelination. We now describe the expression of a recombinant human myelin P2 protein in Escherichia coli, and demonstrate that this protein is recognized by a polyclonal antibody against bovine P2. This recombinant human P2 protein may be used in studies on fatty acid binding to P2, interactions between P2 and other cellular proteins and the role of P2 in demyelinating disorders.

Original languageEnglish (US)
Pages (from-to)841-844
Number of pages4
JournalMedical Science Research
Volume26
Issue number12
StatePublished - Dec 1 1998
Externally publishedYes

Keywords

  • Demyelinating disorders
  • Myelin
  • Recombinant protein

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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