Recombinant human macrophage colony-stimulating factor augments pulmonary host defences against aspergillus fumigatus

Corina E. Gonzalez, Caron A. Lyman, Sondra Lee, Carla Del Guercio, Emmanuel Roilides, John Bacher, Andreas Gehrt, Erwin Feuerstein, Maria Tsokos, Thomas J. Walsh

Research output: Contribution to journalArticle

Abstract

The in vivo and ex vivo effects of macrophage colony-stimulating factor (M-CSF) were studied in a profoundly neutropenic rabbit model in order to determine its potential to augment pulmonary host defence against Aspergillus. M-CSF (100-600 μg/kg/d) was administered prophylactically to neutropenic rabbits with pulmonary aspergillosis starting three days pre-inoculation and then throughout neutropenia. Rabbits receiving M-CSF had significantly increased survival (P=0.01) and decreased pulmonary injury, as measured by decreased pulmonary infarction (P=0.004), when compared with untreated controls. Microscopic studies demonstrated greater numbers of activated pulmonary alveolar macrophages (PAMs) in lung tissue of rabbits receiving M-CSF, in comparison to controls (P

Original languageEnglish (US)
Pages (from-to)87-95
Number of pages9
JournalCytokine
Volume15
Issue number2
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Macrophage Colony-Stimulating Factor
Aspergillus fumigatus
Aspergillus
Rabbits
Lung
Alveolar Macrophages
Pulmonary Infarction
Pulmonary Aspergillosis
Lung Injury
Neutropenia
Tissue
Survival

Keywords

  • Aspergillus
  • Host defense
  • Macrophage-Colony-Stimulating factor
  • Pulmonary

ASJC Scopus subject areas

  • Endocrinology
  • Molecular Biology
  • Immunology
  • Immunology and Allergy

Cite this

Gonzalez, C. E., Lyman, C. A., Lee, S., Del Guercio, C., Roilides, E., Bacher, J., ... Walsh, T. J. (2001). Recombinant human macrophage colony-stimulating factor augments pulmonary host defences against aspergillus fumigatus. Cytokine, 15(2), 87-95. https://doi.org/10.1006/cyto.2001.0889

Recombinant human macrophage colony-stimulating factor augments pulmonary host defences against aspergillus fumigatus. / Gonzalez, Corina E.; Lyman, Caron A.; Lee, Sondra; Del Guercio, Carla; Roilides, Emmanuel; Bacher, John; Gehrt, Andreas; Feuerstein, Erwin; Tsokos, Maria; Walsh, Thomas J.

In: Cytokine, Vol. 15, No. 2, 2001, p. 87-95.

Research output: Contribution to journalArticle

Gonzalez, CE, Lyman, CA, Lee, S, Del Guercio, C, Roilides, E, Bacher, J, Gehrt, A, Feuerstein, E, Tsokos, M & Walsh, TJ 2001, 'Recombinant human macrophage colony-stimulating factor augments pulmonary host defences against aspergillus fumigatus', Cytokine, vol. 15, no. 2, pp. 87-95. https://doi.org/10.1006/cyto.2001.0889
Gonzalez, Corina E. ; Lyman, Caron A. ; Lee, Sondra ; Del Guercio, Carla ; Roilides, Emmanuel ; Bacher, John ; Gehrt, Andreas ; Feuerstein, Erwin ; Tsokos, Maria ; Walsh, Thomas J. / Recombinant human macrophage colony-stimulating factor augments pulmonary host defences against aspergillus fumigatus. In: Cytokine. 2001 ; Vol. 15, No. 2. pp. 87-95.
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