Recombinant Activated Factor VII in Cardiac Surgery: A Systematic Review

Oliver Warren, Kaushik Mandal, Vassilis Hadjianastassiou, Lisa Knowlton, Sukhmeet Panesar, Kokotsakis John, Ara Darzi, Thanos Athanasiou

Research output: Contribution to journalArticle

Abstract

Postoperative hemorrhage is a common complication in cardiac surgery, and it is associated with a considerable increase in morbidity, mortality, and cost. Recombinant activated factor VII (rFVIIa) is an emerging hemostatic agent, increasingly used in cardiac surgery. This article systematically reviews the evidence regarding the efficacy, safety, and cost of rFVIIa in this setting. Although definitive evidence from randomized controlled trials is lacking, the use of rFVIIa in patients experiencing refractory postoperative hemorrhage seems promising and relatively safe. However further research is required to definitively establish its clinical utility in the postoperative cardiac patient.

Original languageEnglish (US)
Pages (from-to)707-714
Number of pages8
JournalAnnals of Thoracic Surgery
Volume83
Issue number2
DOIs
StatePublished - Feb 2007
Externally publishedYes

Fingerprint

Factor VIIa
Thoracic Surgery
Postoperative Hemorrhage
Costs and Cost Analysis
Hemostatics
Randomized Controlled Trials
Morbidity
Safety
Mortality
Research
recombinant FVIIa

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Warren, O., Mandal, K., Hadjianastassiou, V., Knowlton, L., Panesar, S., John, K., ... Athanasiou, T. (2007). Recombinant Activated Factor VII in Cardiac Surgery: A Systematic Review. Annals of Thoracic Surgery, 83(2), 707-714. https://doi.org/10.1016/j.athoracsur.2006.10.033

Recombinant Activated Factor VII in Cardiac Surgery : A Systematic Review. / Warren, Oliver; Mandal, Kaushik; Hadjianastassiou, Vassilis; Knowlton, Lisa; Panesar, Sukhmeet; John, Kokotsakis; Darzi, Ara; Athanasiou, Thanos.

In: Annals of Thoracic Surgery, Vol. 83, No. 2, 02.2007, p. 707-714.

Research output: Contribution to journalArticle

Warren, O, Mandal, K, Hadjianastassiou, V, Knowlton, L, Panesar, S, John, K, Darzi, A & Athanasiou, T 2007, 'Recombinant Activated Factor VII in Cardiac Surgery: A Systematic Review', Annals of Thoracic Surgery, vol. 83, no. 2, pp. 707-714. https://doi.org/10.1016/j.athoracsur.2006.10.033
Warren O, Mandal K, Hadjianastassiou V, Knowlton L, Panesar S, John K et al. Recombinant Activated Factor VII in Cardiac Surgery: A Systematic Review. Annals of Thoracic Surgery. 2007 Feb;83(2):707-714. https://doi.org/10.1016/j.athoracsur.2006.10.033
Warren, Oliver ; Mandal, Kaushik ; Hadjianastassiou, Vassilis ; Knowlton, Lisa ; Panesar, Sukhmeet ; John, Kokotsakis ; Darzi, Ara ; Athanasiou, Thanos. / Recombinant Activated Factor VII in Cardiac Surgery : A Systematic Review. In: Annals of Thoracic Surgery. 2007 ; Vol. 83, No. 2. pp. 707-714.
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