TY - JOUR
T1 - Recognizing ADHD in adults with comorbid mood disorders
T2 - Implications for identification and management
AU - Goodman, David W.
AU - Thase, Michael E.
N1 - Funding Information:
David W. Goodman, MD discloses conflicts of interest with Cephalon, Forest Labs, GlaxoSmithKline, McNeil, MLB Communications, Novartis, Schering-Plough, Shire US, Inc., and Wyeth. Michael E. Thase, MD discloses conflicts of interest with AstraZeneca, Bristol-Myers Squibb, Eli Lilly & Company, Forest Pharmaceuticals, Inc., GlaxoSmithKline, Janssen Pharmaceutica, MedAvante, Inc., Neuronetics, Inc., Novartis, Organon International, Pfizer, Schering-Plough, Sepracor, Inc., Shire US, Inc., Supernus Pharmaceuticals, Inc., Transcept Pharmaceuticals, Inc., and Wyeth-Ayerst Laboratories. Dr Thase receives royalty income from American Psychiatric Publishing, Inc., Guilford Publications, Herald House, and W.W. Norton & Company. Dr Thase has provided expert testimony for Phillips Lytle LLP, and Pepper Hamilton LLP. He has received research grants from Eli Lilly & Company, GlaxoSmithKline, the National Institute of Mental Health, and Sepracor, Inc.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2009
Y1 - 2009
N2 - The objective of this study was to assist those in psychiatric clinical practice in the identification and management of attention-deficit/hyperactivity disorder (ADHD) in adults, with an emphasis on ADHD in the presence of comorbid mood disorders in adults. PubMed was searched to identify relevant studies and critical reviews published in English between 1988 and 2008 on the prevalence, persistence, and consequences of ADHD in adults. Additionally, relevant studies and critical reviews pertaining to the treatment of adults with ADHD and the relationships between ADHD and mood disorders with regard to overlapping symptom profiles, comorbidity, and treatment options were identified. The symptoms of ADHD persist into adulthood for a high proportion of children with this disorder. Among adults, the estimated prevalence of clinician-assessed ADHD in the general population is 4% to 5%. Untreated ADHD can adversely affect school and work achievements, diminish self-esteem, damage interpersonal relationships, and significantly reduce quality of life for adults. A significant proportion of adults with mood disorders have comorbid ADHD, and a significant proportion of adults with ADHD have comorbid mood disorders. Few reports have described the outcome of treatment of individuals with ADHD and concurrent mood disorders and no controlled trials were identified. Attention-deficit/hyperactivity disorder in adults can be identified despite resembling, or coexisting with, other psychiatric disorders. The complexities of comorbid psychiatric conditions require careful diagnostic prioritization when developing a comprehensive sequential treatment plan. The current research literature offers little clinical guidance for constructing treatment algorithms.
AB - The objective of this study was to assist those in psychiatric clinical practice in the identification and management of attention-deficit/hyperactivity disorder (ADHD) in adults, with an emphasis on ADHD in the presence of comorbid mood disorders in adults. PubMed was searched to identify relevant studies and critical reviews published in English between 1988 and 2008 on the prevalence, persistence, and consequences of ADHD in adults. Additionally, relevant studies and critical reviews pertaining to the treatment of adults with ADHD and the relationships between ADHD and mood disorders with regard to overlapping symptom profiles, comorbidity, and treatment options were identified. The symptoms of ADHD persist into adulthood for a high proportion of children with this disorder. Among adults, the estimated prevalence of clinician-assessed ADHD in the general population is 4% to 5%. Untreated ADHD can adversely affect school and work achievements, diminish self-esteem, damage interpersonal relationships, and significantly reduce quality of life for adults. A significant proportion of adults with mood disorders have comorbid ADHD, and a significant proportion of adults with ADHD have comorbid mood disorders. Few reports have described the outcome of treatment of individuals with ADHD and concurrent mood disorders and no controlled trials were identified. Attention-deficit/hyperactivity disorder in adults can be identified despite resembling, or coexisting with, other psychiatric disorders. The complexities of comorbid psychiatric conditions require careful diagnostic prioritization when developing a comprehensive sequential treatment plan. The current research literature offers little clinical guidance for constructing treatment algorithms.
KW - ADHD
KW - Adults
KW - Comorbidity
KW - Mood disorders
UR - http://www.scopus.com/inward/record.url?scp=78649272687&partnerID=8YFLogxK
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U2 - 10.3810/pgm.2009.09.2049
DO - 10.3810/pgm.2009.09.2049
M3 - Article
C2 - 19820271
AN - SCOPUS:78649272687
SN - 0032-5481
VL - 121
SP - 31
EP - 41
JO - Postgraduate medicine
JF - Postgraduate medicine
IS - 5
ER -