TY - JOUR
T1 - Recognition and management of adults with Turner syndrome
T2 - From the transition of adolescence through the senior years
AU - Lin, Angela E.
AU - Prakash, Siddharth K.
AU - Andersen, Niels H.
AU - Viuff, Mette H.
AU - Levitsky, Lynne L.
AU - Rivera-Davila, Michelle
AU - Crenshaw, Melissa L.
AU - Hansen, Lars
AU - Colvin, Mary K.
AU - Hayes, Frances J.
AU - Lilly, Evelyn
AU - Snyder, Emma A.
AU - Nader-Eftekhari, Shahla
AU - Aldrich, Melissa B.
AU - Bhatt, Ami B.
AU - Prager, Laura M.
AU - Arenivas, Ana
AU - Skakkebaek, Anne
AU - Steeves, Marcie A.
AU - Kreher, Jeffrey B.
AU - Gravholt, Claus H.
N1 - Funding Information:
This article would not be possible without the support of a large community of providers and stakeholders represented in the Turner Research Network, which includes the Turner Syndrome Society of the United States (TSSUS), and Turner Syndrome Global Alliance (TSGA). Dr. Lin, Dr. Prakash and Dr. Gravholt extend sincere gratitude to every member of their respective Turner syndrome programs. Dr. Lin thanks the families who have provided philanthropic support for the MGH Turner Syndrome Program's efforts to study our oldest patients, and to Erin McNamara, BS, Ibrahim El-Shakawi, MD, and Lea V. Travers, PhD for contributing to the MGH Turner Syndrome Clinic database. Grant support is acknowledged by Dr. Aldrich (NIH R01CA201487). Dr. Gravholt is supported by the Lundbeck Foundation, the Danish Heart Foundation, the Augustinus Foundation, The Toyota Foundation, the Aase og Einar Danielsen Foundation, the Novo Nordisk Foundation (NNF13OC0003234, NNF15OC0016474), “Fonden til lægevidenskabens fremme”, the Familien Hede Nielsen foundation.
Publisher Copyright:
© 2019 Wiley Periodicals, Inc.
PY - 2019/10/1
Y1 - 2019/10/1
N2 - Turner syndrome is recognized now as a syndrome familiar not only to pediatricians and pediatric specialists, medical geneticists, adult endocrinologists, and cardiologists, but also increasingly to primary care providers, internal medicine specialists, obstetricians, and reproductive medicine specialists. In addition, the care of women with Turner syndrome may involve social services, and various educational and neuropsychologic therapies. This article focuses on the recognition and management of Turner syndrome from adolescents in transition, through adulthood, and into another transition as older women. It can be viewed as an interpretation of recent international guidelines, complementary to those recommendations, and in some instances, an update. An attempt was made to provide an international perspective. Finally, the women and families who live with Turner syndrome and who inspired several sections, are themselves part of the broad readership that may benefit from this review.
AB - Turner syndrome is recognized now as a syndrome familiar not only to pediatricians and pediatric specialists, medical geneticists, adult endocrinologists, and cardiologists, but also increasingly to primary care providers, internal medicine specialists, obstetricians, and reproductive medicine specialists. In addition, the care of women with Turner syndrome may involve social services, and various educational and neuropsychologic therapies. This article focuses on the recognition and management of Turner syndrome from adolescents in transition, through adulthood, and into another transition as older women. It can be viewed as an interpretation of recent international guidelines, complementary to those recommendations, and in some instances, an update. An attempt was made to provide an international perspective. Finally, the women and families who live with Turner syndrome and who inspired several sections, are themselves part of the broad readership that may benefit from this review.
KW - Turner syndrome
KW - clinical history
KW - hormone replacement therapy
KW - infertility
KW - sex chromosome abnormality syndrome
KW - transitioning
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U2 - 10.1002/ajmg.a.61310
DO - 10.1002/ajmg.a.61310
M3 - Article
C2 - 31418527
AN - SCOPUS:85071165325
SN - 1552-4825
VL - 179
SP - 1987
EP - 2033
JO - American Journal of Medical Genetics, Part A
JF - American Journal of Medical Genetics, Part A
IS - 10
ER -