Reciprocal positive regulation of hypoxia-inducible factor 1α and insulin-like growth factor 2

David Feldser, Faton Agani, Narayan V. Iyer, Brian Pak, Gloria Ferreira, Gregg L. Semenza

Research output: Contribution to journalArticlepeer-review

Abstract

Hypoxia-inducible factor 1 (HIF-1) activates transcription of genes encoding glucose transporters, glycolytic enzymes, vascular endothelial growth factor, and other proteins involved in O2 homeostasis and tumor progression. The expression and transcriptional activity of the HIF-1α subunit is regulated by the cellular O2 concentration. We demonstrate that insulin, insulin-like growth factor (IGF)-1, and IGF-2 induce expression of HIF-1α, which is required for expression of genes encoding IGF-2, IGF- binding protein (IGFBP)-2 and IGFBP-3. These data provide a novel mechanism by which HIF-1α overexpression may occur in tumor cells and contribute to an autocrine growth factor loop.

Original languageEnglish (US)
Pages (from-to)3915-3918
Number of pages4
JournalCancer Research
Volume59
Issue number16
StatePublished - Aug 15 1999

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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