TY - JOUR
T1 - Receptors, Neurotransmitters and Drug Responses
AU - Snyder, Solomon H.
PY - 1979/3/1
Y1 - 1979/3/1
N2 - ABNORMALITIES in sensitivity to endogenous hormones and neurotransmitters as well as to exogenous drugs pervade clinical medicine. Idiosyncratic responses to medication are well known, but their causes are rarely ascertained. Although chronic decreases in sensitivity to drugs accompany classic forms of drug addiction, underlying mechanisms are unknown. Acute tolerance, also known as tachyphylaxis or desensitization, is fundamental to synaptic transmission and has many clinical manifestations, such as the decreased responsiveness of an asthmatic person to epinephrine after multiple administrations. Supersensitivity to endogenous or exogenous agents also has clinical relevance. Examples include the apparent supersensitivity to circulating catecholamines in hyperthyroidism and.
AB - ABNORMALITIES in sensitivity to endogenous hormones and neurotransmitters as well as to exogenous drugs pervade clinical medicine. Idiosyncratic responses to medication are well known, but their causes are rarely ascertained. Although chronic decreases in sensitivity to drugs accompany classic forms of drug addiction, underlying mechanisms are unknown. Acute tolerance, also known as tachyphylaxis or desensitization, is fundamental to synaptic transmission and has many clinical manifestations, such as the decreased responsiveness of an asthmatic person to epinephrine after multiple administrations. Supersensitivity to endogenous or exogenous agents also has clinical relevance. Examples include the apparent supersensitivity to circulating catecholamines in hyperthyroidism and.
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U2 - 10.1056/NEJM197903013000904
DO - 10.1056/NEJM197903013000904
M3 - Review article
C2 - 32488
AN - SCOPUS:0018771841
VL - 300
SP - 465
EP - 472
JO - New England Journal of Medicine
JF - New England Journal of Medicine
SN - 0028-4793
IS - 9
ER -