Receptor-mediated protein transport in the early secretory pathway

Andrea C. Baines, Bin Zhang

Research output: Contribution to journalReview article

Abstract

Many secretory proteins are thought to rely upon transmembrane cargo receptors for efficient endoplasmic reticulum (ER)-to-Golgi transport. These receptors recognize specific cargo-encoded sorting signals. Only a few such cargo receptors have been characterized in detail, most of them in yeast. The only well-defined cargo receptor from mammalian cells, the LMAN1-MCFD2 complex, is required for the efficient secretion of coagulation factors V and VIII. Studies of this complex, coupled with recent advances in elucidating the basic machinery that mediates ER-to-Golgi transport, have provided a more-detailed picture of the mechanisms underlying receptor-mediated transport in the early secretory pathway. In addition to yeast studies, insights have also come from investigations into several inherited disorders that have recently been attributed to defects in the secretory pathway.

Original languageEnglish (US)
Pages (from-to)381-388
Number of pages8
JournalTrends in Biochemical Sciences
Volume32
Issue number8
DOIs
StatePublished - Aug 1 2007
Externally publishedYes

Fingerprint

Secretory Pathway
Protein Transport
Endoplasmic Reticulum
Yeast
Yeasts
Factor V
Factor VIII
Sorting
Machinery
Proteins
Cells
Defects

ASJC Scopus subject areas

  • Biochemistry

Cite this

Receptor-mediated protein transport in the early secretory pathway. / Baines, Andrea C.; Zhang, Bin.

In: Trends in Biochemical Sciences, Vol. 32, No. 8, 01.08.2007, p. 381-388.

Research output: Contribution to journalReview article

Baines, Andrea C. ; Zhang, Bin. / Receptor-mediated protein transport in the early secretory pathway. In: Trends in Biochemical Sciences. 2007 ; Vol. 32, No. 8. pp. 381-388.
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