TY - JOUR
T1 - Receptor-Mediated Clearance of Aspergillus Galactomannan
AU - Bennett, John E.
AU - Friedman, Marc M.
AU - Dupont, Bertrand
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1987/5
Y1 - 1987/5
N2 - The fate of radiolabeled Aspergillus fumigatus galactomannan was studied after intravenous injection into rabbits and rats. At 1 hr, the liver contained 35% of the injected dose in rabbits and 30% in rats. Excretion of galactomannan into the urine, measured in rabbits, was another major catabolic route and accounted for 35% of the dose by 24 hr. Immunization of rabbits increased hepatic uptake and decreased urinary excretion. Hepatic uptake in unimmunized rats could be decreased by Saccharomyces cerevisiae mannan, α-methylmannoside, and N-acetylglucosamine, known inhibitors of the macrophage mannose receptor. Autoradiography showed hepatic radiolabeled galactomannan to be concentrated in Kupffer cells, whichexpress the mannosyl receptor for glycoproteins. Macrophage mannosyl receptors may constitute a general mechanism for clearing fungal mannans from the bloodstream.
AB - The fate of radiolabeled Aspergillus fumigatus galactomannan was studied after intravenous injection into rabbits and rats. At 1 hr, the liver contained 35% of the injected dose in rabbits and 30% in rats. Excretion of galactomannan into the urine, measured in rabbits, was another major catabolic route and accounted for 35% of the dose by 24 hr. Immunization of rabbits increased hepatic uptake and decreased urinary excretion. Hepatic uptake in unimmunized rats could be decreased by Saccharomyces cerevisiae mannan, α-methylmannoside, and N-acetylglucosamine, known inhibitors of the macrophage mannose receptor. Autoradiography showed hepatic radiolabeled galactomannan to be concentrated in Kupffer cells, whichexpress the mannosyl receptor for glycoproteins. Macrophage mannosyl receptors may constitute a general mechanism for clearing fungal mannans from the bloodstream.
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U2 - 10.1093/infdis/155.5.1005
DO - 10.1093/infdis/155.5.1005
M3 - Article
C2 - 3549914
AN - SCOPUS:0023212721
SN - 0022-1899
VL - 155
SP - 1005
EP - 1010
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 5
ER -