Receptor-ligand binding: 'Catch' bonds finally caught

Konstantinos Konstantopoulos; William D. Hanley; Denis Wirtz

doi:10.1016/S0960-9822(03)00529-3

Receptor-ligand binding: 'Catch' bonds finally caught

Konstantinos Konstantopoulos, William D. Hanley, Denis Wirtz

Whiting School of Engineering

Research output: Contribution to journal › Review article › peer-review

58 Scopus citations

Abstract

Leukocyte recruitment to sites of inflammation is initiated by the selectin family of adhesion receptors. Recent research reveals that P-selectin binding to its ligand exhibits 'catch' to 'slip' bond transition that may help explain the shear threshold phenomenon.

Original language	English (US)
Pages (from-to)	R611-R613
Journal	Current Biology
Volume	13
Issue number	15
DOIs	https://doi.org/10.1016/S0960-9822(03)00529-3
State	Published - Aug 5 2003

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Agricultural and Biological Sciences(all)

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10.1016/S0960-9822(03)00529-3

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title = "Receptor-ligand binding: 'Catch' bonds finally caught",

abstract = "Leukocyte recruitment to sites of inflammation is initiated by the selectin family of adhesion receptors. Recent research reveals that P-selectin binding to its ligand exhibits 'catch' to 'slip' bond transition that may help explain the shear threshold phenomenon.",

author = "Konstantinos Konstantopoulos and Hanley, {William D.} and Denis Wirtz",

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T1 - Receptor-ligand binding

T2 - 'Catch' bonds finally caught

AU - Konstantopoulos, Konstantinos

AU - Hanley, William D.

AU - Wirtz, Denis

PY - 2003/8/5

Y1 - 2003/8/5

N2 - Leukocyte recruitment to sites of inflammation is initiated by the selectin family of adhesion receptors. Recent research reveals that P-selectin binding to its ligand exhibits 'catch' to 'slip' bond transition that may help explain the shear threshold phenomenon.

AB - Leukocyte recruitment to sites of inflammation is initiated by the selectin family of adhesion receptors. Recent research reveals that P-selectin binding to its ligand exhibits 'catch' to 'slip' bond transition that may help explain the shear threshold phenomenon.

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U2 - 10.1016/S0960-9822(03)00529-3

DO - 10.1016/S0960-9822(03)00529-3

M3 - Review article

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SN - 0960-9822

VL - 13

SP - R611-R613

JO - Current Biology

JF - Current Biology

IS - 15

ER -

Receptor-ligand binding: 'Catch' bonds finally caught

Abstract

ASJC Scopus subject areas

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