Receptor imaging by positron emission tomography and single-photon emission computed tomography

J. J. Frost

Research output: Contribution to journalArticlepeer-review

Abstract

Positron emission tomography (PET) has been used primarily to measure regional brain metabolism and blood flow. Single-photon emission computed tomography (SPECT) also can be used to measure brain perfusion. Receptor imaging by PET and SPECT, however, offers distinctive advantages over the more established flow/metabolism imaging methods, including improved chemical specificity and improved sensitivity in detecting changes in disease. Radioligands are available for PET and SPECT imaging of many neuroreceptors, including the opiate receptor, the dopamine receptor, and the muscarinic cholinergic receptor. A new focus of interest is the imaging and quantification of presynaptic neurotransmitter reuptake sites.

Original languageEnglish (US)
JournalInvestigative Radiology
Volume27
Issue numberSUPPL. 2
StatePublished - 1992

Keywords

  • imaging
  • neuroreceptors
  • positron emission tomography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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