Receptor imaging by pet and spect: Focus on the opiate receptor

J. James Frost

Research output: Contribution to journalArticle

Abstract

Receptor imaging by PET and SPECT offers distinctive advantages over the more established flow/metabolism imaging methods, including improved chemical specificity and improved sensitivity in detecting changes in disease. Radioligands are available for PET and SPECT imaging of many neuroreceptors including the opiate receptor, the dopamine receptor and the muscarinic cholinergic receptor. A new focus of interest is the imaging and quantification of presynaptic neurotransmitter reuptake sites. Clinical applications of μ opiate receptor imaging are discussed for epilepsy, Alzheimer's disease and dementia.

Original languageEnglish (US)
Pages (from-to)39-53
Number of pages15
JournalJournal of Receptor and Signal Transduction Research
Volume13
Issue number1-4
DOIs
StatePublished - 1993

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology
  • Pharmacology

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