Recent progress in the biology and physiology of sirtuins

Toren Finkel; Chu Xia Deng; Raul Mostoslavsky

doi:10.1038/nature08197

Recent progress in the biology and physiology of sirtuins

Toren Finkel, Chu Xia Deng, Raul Mostoslavsky

Research output: Contribution to journal › Article › peer-review

1071 Scopus citations

Abstract

The sirtuins are a highly conserved family of NAD + -dependent enzymes that regulate lifespan in lower organisms. Recently, the mammalian sirtuins have been connected to an ever widening circle of activities that encompass cellular stress resistance, genomic stability, tumorigenesis and energy metabolism. Here we review the recent progress in sirtuin biology, the role these proteins have in various age-related diseases and the tantalizing notion that the activity of this family of enzymes somehow regulates how long we live.

Original language	English (US)
Pages (from-to)	587-591
Number of pages	5
Journal	Nature
Volume	460
Issue number	7255
DOIs	https://doi.org/10.1038/nature08197
State	Published - Jul 30 2009
Externally published	Yes

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Recent progress in the biology and physiology of sirtuins

Abstract

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