Recent progress in the biology and physiology of sirtuins

Toren Finkel, Chu Xia Deng, Raul Mostoslavsky

Research output: Contribution to journalArticle


The sirtuins are a highly conserved family of NAD + -dependent enzymes that regulate lifespan in lower organisms. Recently, the mammalian sirtuins have been connected to an ever widening circle of activities that encompass cellular stress resistance, genomic stability, tumorigenesis and energy metabolism. Here we review the recent progress in sirtuin biology, the role these proteins have in various age-related diseases and the tantalizing notion that the activity of this family of enzymes somehow regulates how long we live.

Original languageEnglish (US)
Pages (from-to)587-591
Number of pages5
Issue number7255
StatePublished - Jul 30 2009
Externally publishedYes


ASJC Scopus subject areas

  • General

Cite this

Finkel, T., Deng, C. X., & Mostoslavsky, R. (2009). Recent progress in the biology and physiology of sirtuins. Nature, 460(7255), 587-591.