Recent progress in magnetic resonance imaging of the embryonic and neonatal mouse brain

Dan Wu, Jiangyang Zhang

Research output: Contribution to journalArticle

Abstract

The laboratory mouse has been widely used as a model system to investigate the genetic control mechanisms of mammalian brain development. Magnetic resonance imaging (MRI) is an important tool to characterize changes in brain anatomy in mutant mouse strains and injury progression in mouse models of fetal and neonatal brain injury. Progress in the last decade has enabled us to acquire MRI data with increasing anatomical details from the embryonic and neonatal mouse brain. High-resolution ex vivo MRI, especially with advanced diffusion MRI methods, can visualize complex microstructural organizations in the developing mouse brain. In vivo MRI of the embryonic mouse brain, which is critical for tracking anatomical changes longitudinally, has become available. Applications of these techniques may lead to further insights into the complex and dynamic processes of brain development.

Original languageEnglish (US)
Article number18
JournalFrontiers in Neuroanatomy
Volume10
Issue numberMAR
DOIs
StatePublished - Mar 3 2016

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Keywords

  • Brain anatomy
  • Brain development
  • Embryonic mouse brain
  • High resolution
  • Magnetic resonance imaging
  • Microscopy

ASJC Scopus subject areas

  • Anatomy
  • Neuroscience (miscellaneous)
  • Cellular and Molecular Neuroscience

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