Recent progress in Alzheimer's disease: Animal models lead the way

Research output: Contribution to journalReview articlepeer-review


Alzheimer's disease (AD) is a worldwide major public health problem. Much recent research has focused on amyloid precursor protein (APP), the secretase enzymes that cleave APP to generate Aβ peptides, and the roles of these peptides in neurotoxicity. Specifically, there has been great interest in the pathogenic role of Aβ peptide oligomers and influences of apoE4 and other Aβ clearance enzymes on Aβ amyloidosis. Genetically engineered animal models are a central tool for studies into the disease mechanisms and for testing experimental therapeutics.

Original languageEnglish (US)
Pages (from-to)145-149
Number of pages5
JournalDrug Discovery Today: Disease Models
Issue number2
StatePublished - Nov 2004

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery


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