Recent progress in Alzheimer's disease: Animal models lead the way

Research output: Contribution to journalArticle

Abstract

Alzheimer's disease (AD) is a worldwide major public health problem. Much recent research has focused on amyloid precursor protein (APP), the secretase enzymes that cleave APP to generate Aβ peptides, and the roles of these peptides in neurotoxicity. Specifically, there has been great interest in the pathogenic role of Aβ peptide oligomers and influences of apoE4 and other Aβ clearance enzymes on Aβ amyloidosis. Genetically engineered animal models are a central tool for studies into the disease mechanisms and for testing experimental therapeutics.

Original languageEnglish (US)
Pages (from-to)145-149
Number of pages5
JournalDrug Discovery Today: Disease Models
Volume1
Issue number2
DOIs
StatePublished - Nov 2004

Fingerprint

Alzheimer Disease
Animal Models
Peptides
Apolipoprotein E4
Amyloid Precursor Protein Secretases
Genetically Modified Animals
Amyloid beta-Protein Precursor
Amyloidosis
Enzymes
Public Health
Research
Therapeutics

ASJC Scopus subject areas

  • Drug Discovery
  • Molecular Medicine

Cite this

Recent progress in Alzheimer's disease : Animal models lead the way. / Li, Tong.

In: Drug Discovery Today: Disease Models, Vol. 1, No. 2, 11.2004, p. 145-149.

Research output: Contribution to journalArticle

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