Recent progress and new perspectives in studying T cell responses to allografts: Minireview

A. Valujskikh, W. M. Baldwin, R. L. Fairchild

Research output: Contribution to journalArticlepeer-review

Abstract

Studies in the past decade advanced our understanding of the development, execution and regulation of T-cell-mediated allograft rejection. This review outlines recent progress and focuses on three major areas of investigation that are likely to guide the development of graft-prolonging therapies in the future. The discussed topics include the contribution of recently discovered molecules to the activation and functions of alloreactive T cells, the emerging problem of alloreactive memory T cells and recently gained insights into the old question of transplantation tolerance.

Original languageEnglish (US)
Pages (from-to)1117-1125
Number of pages9
JournalAmerican Journal of Transplantation
Volume10
Issue number5
DOIs
StatePublished - May 2010
Externally publishedYes

Keywords

  • Acute cellular rejection
  • Memory T cells
  • T-cell immunity and transplantation
  • Tolerance

ASJC Scopus subject areas

  • Transplantation
  • Immunology and Allergy
  • Pharmacology (medical)

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