Abstract
Studies in the past decade advanced our understanding of the development, execution and regulation of T-cell-mediated allograft rejection. This review outlines recent progress and focuses on three major areas of investigation that are likely to guide the development of graft-prolonging therapies in the future. The discussed topics include the contribution of recently discovered molecules to the activation and functions of alloreactive T cells, the emerging problem of alloreactive memory T cells and recently gained insights into the old question of transplantation tolerance.
Original language | English (US) |
---|---|
Pages (from-to) | 1117-1125 |
Number of pages | 9 |
Journal | American Journal of Transplantation |
Volume | 10 |
Issue number | 5 |
DOIs | |
State | Published - May 2010 |
Externally published | Yes |
Keywords
- Acute cellular rejection
- Memory T cells
- T-cell immunity and transplantation
- Tolerance
ASJC Scopus subject areas
- Transplantation
- Immunology and Allergy
- Pharmacology (medical)