Recent herpes simplex virus type 2 infection and the risk of human immunodeficiency virus type 1 acquisition in India

Steven J. Reynolds, Arun R. Risbud, Mary E. Shepherd, Jonathan M. Zenilman, Ronald S. Brookmeyer, Ramesh S. Paranjape, Anand D. Divekar, Raman R. Gangakhedkar, Manisha V. Ghate, Robert C. Bollinger, Sanjay M. Mehendale

Research output: Contribution to journalArticle

Abstract

To estimate the impact of prevalent and incident herpes simplex virus type 2 (HSV-2) infection on the acquisition of human immunodeficiency virus type 1 (HIV-1), stored serum samples from a cohort of 2732 HIV-1-seronegative patients attending 3 sexually transmitted infection clinics and 1 reproductive tract infection clinic in Pune, India, were screened for HSV-2-specific antibodies. Incident HSV-2 infection was defined serologically as "recent" if a negative result of testing for HSV-2 could be documented within the previous 6 months or "remote" if >6 months had elapsed since the last negative test result. The prevalence of HSV-2 at enrollment was 43%. The HSV-2 incidence was 11.4 cases/100 person-years, and the HIV-1 incidence was 5.8 cases/100 person-years. The adjusted hazard ratios of HIV-1 acquisition from exposure to HSV-2 infection were 1.67 for prevalent HSV-2, 1.92 for remote incident HSV-2, and 3.81 for recent incident HSV-2. Recent incident HSV-2 infection was associated with the highest risk of HIV-1 in this study, which suggests that prevention of HSV-2 infection may reduce the risk of HIV-1 acquisition.

Original languageEnglish (US)
Pages (from-to)1513-1521
Number of pages9
JournalJournal of Infectious Diseases
Volume187
Issue number10
DOIs
StatePublished - May 15 2003

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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    Reynolds, S. J., Risbud, A. R., Shepherd, M. E., Zenilman, J. M., Brookmeyer, R. S., Paranjape, R. S., Divekar, A. D., Gangakhedkar, R. R., Ghate, M. V., Bollinger, R. C., & Mehendale, S. M. (2003). Recent herpes simplex virus type 2 infection and the risk of human immunodeficiency virus type 1 acquisition in India. Journal of Infectious Diseases, 187(10), 1513-1521. https://doi.org/10.1086/368357