Recent developments in the search for a cure for HIV-1 infection: Targeting the latent reservoir for HIV-1

Research output: Contribution to journalReview article

Abstract

HIV-1 infection can now be readily controlled with combination antiretroviral therapy. However, the virus persists indefinitely in a stable latent reservoir in resting CD4+ T cells. This reservoir generally prevents cure of the infection with combination antiretroviral therapy alone. However, several recent cases of potential HIV-1 cure have generated renewed optimism. Here we review these cases and consider new developments in our understanding of the latent reservoir. In addition, we consider clinical aspects of curative strategies to provide a more realistic picture of what a generally applicable cure for HIV-1 infection is likely to entail.

Original languageEnglish (US)
Pages (from-to)12-19
Number of pages8
JournalJournal of Allergy and Clinical Immunology
Volume134
Issue number1
DOIs
StatePublished - Jul 2014

Keywords

  • HIV
  • antiretroviral therapy
  • cure
  • eradication
  • latency
  • reservoir
  • stem cell transplantation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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